Anti-ACTR1B antibody produced in rabbit
SIGMA/AV52099 - affinity isolated antibody
Synonym: Anti-ARP1 actin-related protein 1 homolog B, centractin β (yeast); Anti-ARP1B; Anti-CTRN2
Product Type: Chemical
Immunoblotting Cell Type: HepG2 (Cat. No. AV52099). Lanes 1. Antibody dilution (concentration) 0.5 μg/mL in cell type HepG2
Immunoblotting ACTR1B: Cat. No. AV52099: Western blot analysis of ACTR1B in Human 721_B cell lysates with ACTR1B antibody at 1.0 μg/mL.
Immunoblotting ACTR1B: Cat. No. AV52099: Western blot analysis of ACTR1B in Human Fetal Brain cell lysates with ACTR1B antibody at 1.0 μg/mL.
Immunoblotting ACTR1B: Cat. No. AV52099: Western blot analysis of ACTR1B in Human Fetal Heart cell lysates with ACTR1B antibody at 1.0 μg/mL.
Immunoblotting ACTR1B: Cat. No. AV52099: Western blot analysis of ACTR1B in Human Fetal Liver cell lysates with ACTR1B antibody at 1.0 μg/mL.
Immunoblotting ACTR1B: Cat. No. AV52099: Western blot analysis of ACTR1B in Human Fetal Lung cell lysates with ACTR1B antibody at 1.0 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 42 kDa |
| NCBI accession no. | NP_005726   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | dog, bovine, mouse, horse, guinea pig, rat, human, rabbit |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: suitable |
| UniProt accession no. | P42025 |
| Biochem/physiol Actions: | ACTR1B is a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. ACTR1B, like ACTR1A, is an actin-related protein. These two proteins, which are of equal length and share 90% amino acid identity, are present in a constant ratio of approximately 1:15 in the dynactin complex.This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins are of equal length and share 90% amino acid identity. They are present in a constant ratio of approximately 1:15 in the dynactin complex. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the C terminal region of human ACTR1B |
| Other Notes: | Synthetic peptide located within the following region: KIKISAPQERLYSTWIGGSILASLD |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |