Anti-GFRA2 antibody produced in rabbit
SIGMA/AV54575 - affinity isolated antibody
Synonym: Anti-GDNF family receptor α2; Anti-GDNFRB; Anti-NRTNR-ALPHA; Anti-NTNRA; Anti-RETL2; Anti-TRNR2
Product Type: Chemical
Immunoblotting Cell Type: fetal brain (Cat. No. AV54575). Lanes 1. Antibody dilution (concentration) 1 μg/mL in cell type fetal brain
Immunoblotting GFRA2: Cat. No. AV54575: Western blot analysis of GFRA2 in Human Adult Placenta cell lysates with GFRA2 antibody at 1.0 μg/mL.
Immunoblotting GFRA2: Cat. No. AV54575: Western blot analysis of GFRA2 in Human Fetal Muscle cell lysates with GFRA2 antibody at 1.0 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 0.5 mg - 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 47 kDa |
| NCBI accession no. | NP_001486   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | horse, dog, mouse, rat, human, pig, rabbit |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: suitable |
| UniProt accession no. | O00451 |
| Application: | Anti-GFRA2 antibody produced in rabbit is suitable for western blotting at a concentration of 1μg/mL. |
| Biochem/physiol Actions: | GFRA2 are cell surface bound glycoproteins that mediate interactions of the glial-cell-line-derived neurotrophic factor (GDNF) ligand family with the RET receptor that are crucial for the development of kidney and some peripheral nerve lineages. GFRA2 gene is shown to be associated with tardive dyskinesia in a study. The factors GDNF and neurturin, along with their receptors GFRA1 and GFRA2, respectively, are crucial for enteric neuron survival in human colon. The gene is shown to be associated with schizophrenia and clozapine response in a study. It is associated with severe abdominal pain sensation in pancreatic cancer patients. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | Synthetic peptide directed towards the C terminal region of human GFRA2 |
| Other Notes: | Synthetic peptide located within the following region: NVSPKGPSFQATQAPRVEKTPSLPD |
| Physical form: | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |