Bufalin

SIGMA/B0261

Synonym: 3β,14-Dihydroxy-5β,20(22)-bufadienolide; 5β,20(22)-Bufadienolide-3β,14-diol

CAS Number: 465-21-4
Empirical Formula (Hill Notation): C₂₄H₃₄O₄
Molecular Weight: 386.52
MDL Number: MFCD30207876
Linear Formula: C₂₄H₃₄O₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-B0261-10MG	10 mg	$577.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥97% (HPLC)
form	solid
InChI	1S/C24H34O4/c1-22-10-7-17(25)13-16(22)4-5-20-19(22)8-11-23(2)18(9-12-24(20,23)27)15-3-6-21(26)28-14-15/h3,6,14,16-20,25,27H,4-5,7-13H2,1-2H3/t16-,17+,18-,19+,20-,22+,23-,24+/m1/s1
InChI key	QEEBRPGZBVVINN-BMPKRDENSA-N
Quality Level	200
SMILES string	O[C@]([C@@](CC[C@@]1([H])[C@@]2(CC[C@H](O)C1)C)([H])[C@]2([H])CC3)(CC[C@@H]4C(C=C5)=COC5=O)[C@]34C
solubility	DMF: soluble
	DMSO: soluble
	ethanol: soluble
storage temp.	2-8°C

Application:	Bufalin has been used: • to test its effect on invasion and activation of nuclear factor kappa- B (NF-κB) cells and tumor necrosis factor-α (TNF-α) stimulated rheumatoid arthritis fibroblast-like synoviocytes (RAFLSs) • as a nuclear receptor coactivator 3 (NCOA3) inhibitor in chondrocytes • to test its anti-metastasis effect in lung cancer cells (NCI-H460) resistant to gefitinib
Biochem/physiol Actions:	Bufalin is an anti-metastasis drug, which elicits anti-tumor functionality by favoring cell cycle arrest and apoptosis in various cancer types including hepatocellular, bladder and osteosarcoma. It also promotes autophagic cell death and possesses anti-inflammatory properties. Bufalin is a steroid receptor coactivator (SRC) inhibitor.
General description:	Bufalin is a C-24 steroid with an α-pyrone ring positioned at C-17. It is present in the venom glands and skin of toad, Venenum Bufonis. Bufalin is a cardiotonic steroid and is digoxin-like component of Chan Su.

Symbol	GHS06
Signal word	Danger
Hazard statements	H300
Precautionary statements	P301 + P310 + P330
Hazard Codes	T+
Risk Statements	28
Safety Statements	28-36/37-45
RIDADR	UN 3462 6.1 / PGII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥97% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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