Bupropion hydrochloride
SIGMA/B102 - ≥98% (HPLC), solid
Synonym: (±)
CAS Number: 31677-93-7
Empirical Formula (Hill Notation): C13H18ClNO · HCl
Molecular Weight: 276.20
EC Number: 250-759-9
MDL Number: MFCD00055209
Linear Formula: C13H18ClNO · HCl
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: B102-1G
| assay | ≥98% (HPLC) |
| color | white |
| description | Drug Control: Kábítószer / Narcotic Drug (Hungary), 78/2022. (XII. 28.) BM rendelet |
| drug control | Kábítószer / Narcotic Drug (Hungary), 78/2022. (XII. 28.) BM rendelet |
| form | solid |
| InChI | 1S/C13H18ClNO.ClH/c1-9(15 |
| InChI key | HEYVINCGKDONRU-UHFFFAOYSA |
| originator | GlaxoSmithKline |
| Quality Level | 100  |
| SMILES string | Cl[H].CC(NC(C)(C)C)C(=O)c |
| solubility | H2O: 15 mg/mL, clear |
| Application: | Bupropion hydrochloride has been used as an anti-depressant and injected into mice intraperitoneally for forced swim test. It has also been used to study its effects on depression, anxiety and smoking cessation. |
| Biochem/physiol Actions: | Bupropion possesses antidepressant and anxiolytic properties. It serves as a good auxiliary for people who makes an effort to give up smoking. It may also be used in the treatment for attention-deficit hyperactivity disorder. |
| Biochem/physiol Actions: | Inhibits the dopamine and norepinephrine transporters with Kis of 2.8 μM and 1.4 μM, respectively. Does not inhibit the serotonin transporter (Ki = 45 μM). Antidepressant. |
| Features and Benefits: | This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Features and Benefits: | This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Features and Benefits: | This compound was developed by GlaxoSmithKline . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| General description: | Bupropion is structurally linked to the phenylethylamine family. It is a monocyclic aminoketone (chloropropiophenone). |
| Packaging: | 1 g in poly bottle |
| Packaging: | 50, 250 mg in poly bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| UNSPSC | 12352200 |