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(±)-Bay K8644

SIGMA/B112 - calcium channel agonist

Synonym: 1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-[trifluoromethyl]phenyl)pyridine-3-carboxylic acid methyl ester

CAS Number: 71145-03-4
Empirical Formula (Hill Notation): C16H15F3N2O4
Molecular Weight: 356.30
MDL Number: MFCD00036697
Linear Formula: C16H15F3N2O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-B112-5MG 5 mg
 $405.00
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45-B112-25MG 25 mg
 $1530.00
1/EA		 Add To Favorites

 

assay ≥97.5% (HPLC)
color yellow to dark yellow
form powder
InChI 1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3
InChI key ZFLWDHHVRRZMEI-UHFFFAOYSA-N
mp 168-170  °C
Quality Level 100 
SMILES string CC1=C(C(OC)=O)C(C2=CC=CC=C2C(F)(F)F)C([N+]([O-])=O)=C(C)N1
solubility DMSO: 20 mg/mL
  H2O: insoluble
  methanol and ethanol: 63 mg/mL
storage temp. 2-8°C
Application: (±)-Bay K8644 has been used as an agonist for voltage sensitive calcium channels (VSCCs) in interneurons, L-type calcium channel (LTCC) in human embryonic kidney 293 cells and viscerofugal neurons.
Biochem/physiol Actions: (±)-Bay K8644 is a 1,4-dihydropyridine (DHP) derivative and an agonist for L-type Ca2+ channels. However, it′s enantiomers (-)-BAY k8644 and (+)-BAY k8644 have opposing functionality with respect to Ca2+ channels as high-potency agonist and low-potency antagonist, respectively. (±)-Bay K8644 increases influx of Ca2+ specifically at voltage-gated calcium channels. It constricts blood vessels and heart contraction.
Biochem/physiol Actions: Increases influx of Ca2+ specifically at voltage-gated calcium channels.
Packaging: 5, 25 mg in glass bottle
Purity ≥97.5% (HPLC)
mp 168-170  °C
Storage Temp. 2-8°C
UNSPSC 12352202

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