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(S)-(−)-Bay K8644

SIGMA/B133 - ≥98% (HPLC), solid

Synonym: S-(−)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester

CAS Number: 98625-26-4
Empirical Formula (Hill Notation): C16H15F3N2O4
Molecular Weight: 356.30
MDL Number: MFCD00153769
Linear Formula: C16H15F3N2O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-B133-1MG 1 mg
 $252.00
1/EA		 Add To Favorites
45-B133-5MG 5 mg
 $997.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color yellow
form solid
InChI 1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3/t13-/m0/s1
InChI key ZFLWDHHVRRZMEI-ZDUSSCGKSA-N
Quality Level 100 
SMILES string COC(=O)C1=C(C)NC(C)=C([C@H]1c2ccccc2C(F)(F)F)[N+]([O-])=O
solubility ethanol: soluble (Organic solutions are stable for at least 20 days at RT.)
  H2O: slightly soluble
storage temp. 2-8°C
Application: (S)-(-)-Bay K8644 has been used as a L-type calcium channel (LTCC) agonist in the suprachiasmatic nucleus (SCN) slices. It has also been used as a LTCC agonist to induce arrhythmia in rats.
Biochem/physiol Actions: (S)-(-)-Bay K8644 enhances Ca2+ current, whereas the (+)-Bay K 8644 is a weak Ca2+ channel antagonist. Bay K 8644 is lipophilic and it effectively scavenges superoxide anions.
Features and Benefits: This compound is featured on the Calcium Channels  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
General description: (S)-(-)-Bay K8644, a dihydropyridine compound is a Ca2+ channel activator. It is an enantiomer of Bay K 8644.
Legal Information: Manufactured and sold with the permission of Bayer AG.
Packaging: 1, 5 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H315 - H319
Precautionary statements P302 + P352 - P305 + P351 + P338
Hazard Codes Xi
Risk Statements 36/38
Safety Statements 26-36
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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