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H-89 dihydrochloride hydrate

SIGMA/B1427 - ≥98% (HPLC), powder

Synonym: N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide dihydrochloride

CAS Number: 130964-39-5 (anhydrous)
Empirical Formula (Hill Notation): C20H20BrN3O2S · 2HCl · xH2O
Molecular Weight: 519.28 (anhydrous basis)
MDL Number: MFCD11045926
Linear Formula: C20H20BrN3O2S · 2HCl · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-B1427-5MG 5 mg
 $198.00
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assay ≥98% (HPLC)
biological source synthetic (organic)
color off-white
form powder
InChI 1S/C20H20BrN3O2S.2ClH.H2O/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20;;;/h1-10,12,15,22,24H,11,13-14H2;2*1H;1H2/b3-2+;;;
InChI key GKFFJFGBWAGAFD-HZBIHQSRSA-N
Quality Level 100 
SMILES string O.Cl.Cl.Brc1ccc(C=CCNCCNS(=O)(=O)c2cccc3cnccc23)cc1
solubility DMSO: 10 mg/mL, clear
storage temp. 2-8°C
Application: H-89 dihydrochloride hydrate has been used in the inhibition of protein kinase A in Leydig cells, primary calvarial osteoblasts (pOBs), rat granulosa cell line (LH-15 cells) and human umbilical vein endothelial cells (HUVECs).
Biochem/physiol Actions: H-89 dihydrochloride hydrate is a selective inhibitor of protein kinase A (PKA). It also inhibits potassium (K+) current in rat myocytes. It mediates Na+ transport by interacting with α subunits of epithelial Na+ channel (ENaC).
Biochem/physiol Actions: Selective, potent inhibitor of cAMP-dependent protein kinase.
Features and Benefits: This compound is a featured product for Kinase Phosphatase Biology research. Click here  to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the PKA & PKG  and PKB/Akt  pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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