Bone Morphogenetic Protein 7 human
SIGMA/B1434 - >95% (SDS-PAGE), recombinant, expressed in CHO cells, lyophilized powder, suitable for cell culture
Synonym: Bone Morphogenetic Protein 7 human; BMP-7; OP-1; Osteogenic protein 1
MDL Number: MFCD03702812
Product Type: Chemical
TGF-beta Signaling
Research areas: Apoptosis, Differentiation, Epithelial Mesenchymal transition, Cancer biology, Bone remodelling, Developmental biology, Inflammation, Metabolism
Disease areas: Gastrointestinal cancers, Pulmonary, liver and renal fibrosis, Diabetes, Tuberculosis
See also: T7039; H8541; B3555; 11412272001; H4791; H8791
Research areas: Apoptosis, Differentiation, Epithelial Mesenchymal transition, Cancer biology, Bone remodelling, Developmental biology, Inflammation, Metabolism
Disease areas: Gastrointestinal cancers, Pulmonary, liver and renal fibrosis, Diabetes, Tuberculosis
See also: T7039; H8541; B3555; 11412272001; H4791; H8791
| assay | >95% (SDS-PAGE) |
| biological source | human |
| form | lyophilized powder |
| impurities | endotoxin, tested |
| mol wt | 18-20 kDa by SDS-PAGE (reducing) |
| 30-40 kDa by SDS-PAGE (non-reducing) | |
| monomer calculated mol wt 15.7 kDa | |
| packaging | pkg of 10 μg |
| potency | 0.2-0.6 μg/mL ED50 |
| Quality Level | 100  |
| recombinant | expressed in CHO cells |
| storage condition | avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.) |
| storage temp. | −20°C |
| technique(s) | cell culture | mammalian: suitable |
| UniProt accession no. | P18075  |
| Analysis Note: | The biological activity is measured by its ability to induce alkaline phosphatase production using mouse ATDC-5 chondrogenic cells. |
| Biochem/physiol Actions: | Cellular responses to BMP-7 are mediated by the formation of hetero-oligomeric complexes of type I and II serine/threonine kinase receptors. Human and mouse BMP-7 share 98% amino acid sequence identity. |
| Physical form: | Lyophilized from 50.0 μl of a 0.2 μm filtered solution in 35% acetonitrile, 0.1% TFA containing 50 μg bovine serum albumin per 1μg of cytokine. |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 |
| Precautionary statements | P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313 |
| Hazard Codes | F,Xn |
| Risk Statements | 11-20/21/22-36/38 |
| Safety Statements | 22-26-33-36/37-60 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | >95% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |