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[Lys-des-Arg9]-Bradykinin

SIGMA/B1542 - ≥95% (HPLC)

Synonym: des-Arg10-Kallidin

CAS Number: 71800-36-7
Empirical Formula (Hill Notation): C50H73N13O11
Molecular Weight: 1032.20
MDL Number: MFCD00079826
Linear Formula: C50H73N13O11
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-B1542-1MG 1 mg
 $146.00
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assay ≥95% (HPLC)
form powder
InChI 1S/C50H73N13O11/c51-22-8-7-17-33(52)42(66)58-34(18-9-23-55-50(53)54)46(70)63-26-12-21-40(63)48(72)62-25-10-19-38(62)44(68)56-29-41(65)57-35(27-31-13-3-1-4-14-31)43(67)60-37(30-64)47(71)61-24-11-20-39(61)45(69)59-36(49(73)74)28-32-15-5-2-6-16-32/h1-6,13-16,33-40,64H,7-12,17-30,51-52H2,(H,56,68)(H,57,65)(H,58,66)(H,59,69)(H,60,67)(H,73,74)(H4,53,54,55)/t33-,34-,35-,36-,37-,38-,39-,40-/m0/s1
InChI key AILVBOHFGXNHCC-TZPCGENMSA-N
Quality Level 200 
SMILES string NCCCC[C@H](N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CO)C(=O)N4CCC[C@H]4C(=O)N[C@@H](Cc5ccccc5)C(O)=O
storage temp. −20°C
UniProt accession no. P01042 
Amino Acid Sequence: Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe
Application: [Lys-des-Arg9]-Bradykinin has been used as a B1R agonist to investigate the role of B1R in diabetes-induced secondary hemorrhage.
Biochem/physiol Actions: [Des-Arg10]-kallidin or [Lys-des-Arg9]-Bradykinin is a bradykinin B1 receptor agonist. It strongly upregulates the B1 receptor and is blocked by a specific protein kinase C inhibitor. The upregulation is correlated with the induction of transcription nuclear factor κB (NF-κB). Elevation of Lys-des[Arg9]–bradykinin because of airway inflammation in asthma patients is known to modify the immune responses. It affects the migration and production of interleukin-12 in monocyte-derived dendritic cells.
Other Notes: Lyophilized from 0.1% TFA in H2O
Packaging: 1 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (HPLC)
Storage Temp. −20°C
UNSPSC 12352209

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