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Bafilomycin A1 from Streptomyces griseus

SIGMA/B1793 - ≥90% (HPLC)

CAS Number: 88899-55-2
Empirical Formula (Hill Notation): C35H58O9
Molecular Weight: 622.83
MDL Number: MFCD06795130
Linear Formula: C35H58O9
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-B1793-2UG 2 µg
 $89.20
1/EA		 Add To Favorites
45-B1793-10UG 10 µg
 $216.00
1/EA		 Add To Favorites
Bafilomycin A1 is a specific inhibitor of the vacuolar-type H+-ATPase (V-ATPase), an enzyme responsible for acidification of intracellular compartments, including lysosomes and endosomes. Inhibition of V-ATPase by bafilomycin A1 prevents the acidification process, resulting in altered lysosomal function. impaired protein degradation, and autophagy inhibition.

 

antibiotic activity spectrum fungi
assay ≥90% (HPLC)
form film
InChI 1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H3/b14-12+,20-13+,21-16+,29-17-/t22-,23+,24-,25-,26-,27+,28-,30-,31+,32+,33+,35+/m0/s1
InChI key XDHNQDDQEHDUTM-JQWOJBOSSA-N
mode of action DNA synthesis | interferes
  enzyme | inhibits
Quality Level 300 
SMILES string CO[C@H]1C=CC=C(C)C[C@H](C)[C@H](O)[C@H](C)C=C(C)C=C(OC)C(=O)OC1[C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](O)[C@H](C)[C@H](O2)C(C)C
storage temp. −20°C
Application: Bafilomycin A1 has been used:
• as an autophagy inhibitor to study its effects on hepatic steatosis in human hepatocytes
• as a vacuolar-type H+ -ATPase inhibitor to study its effects on the cell viability, percentage of PI-positive cells, and glucose-stimulated insulin secretion (GSIS) in mice INS-1 cells
• as a vacuolar-type H+ -ATPase inhibitor to study its effects on tau degradation in human SH-SY5Y cells

Biochem/physiol Actions: A specific inhibitor of vacuolar type H+-ATPase (V-ATPase) in animal cells, plant cells and microorganisms.
Biochem/physiol Actions: Bafilomycin A1 inhibits autophagosome-lysosome fusion and autolysosome acidification, the steps involved in the autophagic process that is required for maintaining functional autophagic flux and cellular homeostasis.
Biochem/physiol Actions: Specific inhibitor of vacuolar type H+-ATPase (V-ATPase).
General description: Chemical structure: macrolide
Other Notes: 2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research 
Packaging: 2, 10 μg in serum bottle
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Purity ≥90% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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