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Biotin Polyethyleneoxide Iodoacetamide

SIGMA/B2059

Synonym: Biotin PEO Iodoacetamide

Empirical Formula (Hill Notation): C18H31IN4O5S
Molecular Weight: 542.43
MDL Number: MFCD04974830
Linear Formula: C18H31IN4O5S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-B2059-50MG 50 mg
 $348.00
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description Sulfhydryl specific, water soluble biotinylation reagent
form powder
InChI 1S/C18H31IN4O5S/c19-11-16(25)21-6-8-28-10-9-27-7-5-20-15(24)4-2-1-3-14-17-13(12-29-14)22-18(26)23-17/h13-14,17H,1-12H2,(H,20,24)(H,21,25)(H2,22,23,26)
InChI key LWGLKVINXNMNJX-UHFFFAOYSA-N
Quality Level 200 
SMILES string ICC(=O)NCCOCCOCCNC(=O)CCCCC1SCC2NC(=O)NC12
solubility H2O: 10 mg/mL
storage temp. 2-8°C
Application: • Incorporates a 12 atom hydrophilic spacer.
• Typically coupled to sulfhydryl groups at pH 7.5 - 8.5
• Especially useful for cysteine labeling in many proteomics type applications such as peptide mapping and mass spectrometry.
Application: Biotin Polyethyleneoxide Iodoacetamide has been used as a thiol reactive reagent to demonstrate the presence of free thiols in capsid protein L1 of human papillomavirus 16. It has been used for biotinylation of proteins for ELISA (enzyme-linked immunosorbent assay) competition and pull down experiments.
Biochem/physiol Actions: Biotin polyethyleneoxide (PEO) iodoacetamide group reacts specifically with reduced thiols at pH 7.5 - 8.5. Peptides and small molecules containing thiol groups may also be labeled using this reagent. The biotin PEO iodoacetamide enables tagging of cysteine residues and conjugation to sulfhydryls in proteins making it useful in proteomics, peptide mapping, phosphopeptide analysis, and mass spectrometry.
General description: Biotin polyethyleneoxide (PEO) iodoacetamide is a sulfhydryl (thiol) specific biotinylation reagent.
Storage Temp. 2-8°C
UNSPSC 12352119

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