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5-(2-Benzothiazolyl)-3-ethyl-2-[2-(methylphenylamino)ethenyl]-1-phenyl-1H-benzimidazolium iodide

SIGMA/B2311 - ≥98% (HPLC)

CAS Number: 681281-88-9
Empirical Formula (Hill Notation): C31H27IN4S
Molecular Weight: 614.54
MDL Number: MFCD00570739
Linear Formula: C31H27IN4S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-B2311-5MG 5 mg
 $170.00
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assay ≥98% (HPLC)
color yellow to orange
form powder
InChI 1S/C31H27N4S.HI/c1-3-34-28-22-23(31-32-26-16-10-11-17-29(26)36-31)18-19-27(28)35(25-14-8-5-9-15-25)30(34)20-21-33(2)24-12-6-4-7-13-24;/h4-22H,3H2,1-2H3;1H/q+1;/p-1
InChI key NAYRELMNTQSBIN-UHFFFAOYSA-M
Quality Level 100 
SMILES string [I-].CC[n+]1c(C=CN(C)c2ccccc2)n(-c3ccccc3)c4ccc(cc14)-c5nc6ccccc6s5
solubility DMSO: 5 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: 5-(2-Benzothiazolyl)-3-et<WBR>hyl-2-[2-(methylphenylami<WBR>no)-ethenyl]-1-phenyl-1H-<WBR>benzimidazolium, or Akt Inhibitor IV, is a cell-permeable benzimidazole compound that inhibits Akt phosphorylation/activatio<WBR>n by targeting the ATP binding site of a kinase upstream of Akt, but downstream of PI3K. Shown to block Akt-mediated FOXO1a nuclear export (IC<SUB>50</SUB> = 0.625μM) and cell proliferation (IC<SUB>50</SUB> < 1.25μM) in 786-O cells. Unlike phosphatidylinositol analog-based Akt inhibitors, this inhibitor does not affect PI3K.
Biochem/physiol Actions: 5-(2-Benzothiazolyl)-3-ethyl-2-[2-(methylphenylamino)ethenyl]-1-phenyl-1H-benzimidazolium iodide, or Akt Inhibitor IV, is a cell-permeable benzimidazole compound that inhibits Akt phosphorylation/activation by targeting the ATP binding site of a kinase upstream of Akt, but downstream of PI3K.
Features and Benefits: This compound is featured on the PKB/Akt  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5 mg in glass bottle
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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