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L-Buthionine-sulfoximine

SIGMA/B2515 - ≥97% (TLC)

Synonym: L-BSO

CAS Number: 83730-53-4
Empirical Formula (Hill Notation): C8H18N2O3S
Molecular Weight: 222.31
MDL Number: MFCD00067000
Linear Formula: C8H18N2O3S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-B2515-500MG 500 mg
 $290.00
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45-B2515-1G 1 g
 $456.00
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45-B2515-5G 5 g
 $1600.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: B2515-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: B2515-500MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: B2515-5G

 

assay ≥97% (TLC)
biological source synthetic (organic)
form powder
InChI 1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)/t7-,14?/m0/s1
InChI key KJQFBVYMGADDTQ-CVSPRKDYSA-N
mp 224-226  °C
Quality Level 200 
shipped in wet ice
SMILES string CCCCS(=N)(=O)CC[C@H](N)C(O)=O
solubility water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
storage temp. −20°C
Application: L-Buthionine-sulfoximine has been used:
• as a selective activator for the induction of ferroptosis in rat apoptotic cells
• as an inhibitor of γ-glutamylcysteine synthetase to study its effects on the viability and effectiveness of microspore embryogenesis (ME) induction in triticale and barley
• as a glutathione synthesis blocker to study its effects on auranofin (AFN)-mediated interleukin-1β expression in murine alveolar macrophages
Application: Used to induce experimental glutathione deficiency, to investigate roles of glutathione in cellular processes.
Biochem/physiol Actions: Blocks cellular resistance to chemotherapy by inhibiting γ-glutamylcysteine synthetase, a key enzyme in glutathione biosynthesis. Used to induce experimental glutathione deficiency, to investigate roles of glutathione in cellular processes.
Packaging: 1, 5 g in poly bottle
Packaging: 500 mg in poly bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97% (TLC)
mp 224-226  °C
Storage Temp. −20°C
UNSPSC 12352202

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