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DL-Buthionine-(S,R)-sulfoximine

SIGMA/B2640

CAS Number: 5072-26-4
Empirical Formula (Hill Notation): C8H18N2O3S
Molecular Weight: 222.31
MDL Number: MFCD00070309
Linear Formula: CH3(CH2)3S(O)(=NH)CH2CH2CH(NH2)CO2H
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-B2640-500MG 500 mg
 $142.00
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45-B2640-1G 1 g
 $243.00
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45-B2640-5G 5 g
 $958.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: B2640-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: B2640-500MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: B2640-5G

 

assay ≥98% (TLC)
biological source synthetic (organic)
form powder
InChI 1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)
InChI key KJQFBVYMGADDTQ-UHFFFAOYSA-N
mp 215 °C (dec.) (lit.)
Quality Level 200 
SMILES string CCCCS(=N)(=O)CCC(N)C(O)=O
solubility water: 50 mg/mL, clear to very slightly hazy, colorless to yellow
storage temp. 2-8°C
Application: DL-Buthionine-(S,R)-sulfoximine has also been used:
• to induce oxidative stress in Starlings
• to deplete choroidal glutathione (GSH) in two-day-old rat pups
• to test its inhibitory effect on the enzymes, γ-glutamylcysteine synthetase and trypanothione synthetase (TryS) from T. cruzi
Application: DL-Buthionine-(S,R)-sulfoximine has been used to deplete cellular glutathione levels in retinal ganglion cell 5 (RGC-5) cell line.
Biochem/physiol Actions: Depletes cellular glutathione and downregulates GST level.
Features and Benefits: This compound is a featured product for ADME Tox research. Click here  to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
General description: DL-buthionine-SR-sulfoximine (BSO) is an amino acid analogue, which acts as an inhibitor of γ-glutamylcysteine synthetase. BSO increases the sensitivity of Trypanosoma cruzi to antiparasitic drugs, such as nifurtimox or benznidazole.
Packaging: 1, 5 g in poly bottle
Packaging: 500 mg in poly bottle
Purity ≥98% (TLC)
mp 215 °C (dec.) (lit.)
Storage Temp. 2-8°C
UNSPSC 12161501

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