Biotinamidohexanoic acid N-hydroxysuccinimide ester

SIGMA/B2643 - ≥98% (TLC), powder

Synonym: (+)-Biotinamidocaproate N-hydroxysuccinimidyl ester; N-(+)-Biotinyl-6-aminocaproic acid N-succinimidyl ester; N-(+)-Biotinyl-6-aminohexanoic acid NHS ester; N-Succinimidyl N-biotinyl-6-aminocaproate; Succinimidyl 6-(biotinamido)hexanoate

CAS Number: 72040-63-2
Empirical Formula (Hill Notation): C₂₀H₃₀N₄O₆S
Molecular Weight: 454.54
MDL Number: MFCD00065502
Linear Formula: C₂₀H₃₀N₄O₆S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-B2643-10MG	10 mg	$46.90 1/EA	Add To Favorites
45-B2643-25MG	25 mg	$125.00 1/EA	Add To Favorites
45-B2643-100MG	100 mg	$337.00 1/EA	Add To Favorites
45-B2643-250MG	250 mg	$675.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: B2643-100MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (TLC)
form	powder
InChI	1S/C20H30N4O6S/c25-15(7-4-3-6-14-19-13(12-31-14)22-20(29)23-19)21-11-5-1-2-8-18(28)30-24-16(26)9-10-17(24)27/h13-14,19H,1-12H2,(H,21,25)(H2,22,23,29)/t13-,14-,19-/m0/s1
InChI key	UVGHPGOONBRLCX-NJSLBKSFSA-N
Quality Level	200
SMILES string	[H][C@]12CS[C@@H](CCCCC(=O)NCCCCCC(=O)ON3C(=O)CCC3=O)[C@@]1([H])NC(=O)N2
solubility	DMF: 50 mg/mL (Stable up to 2 months in dry DMF.)
	H₂O: ≤2 mg/mL (with sonication)
storage temp.	−20°C

Application:	Biotinamidohexanoic acid N-hydroxysuccinimide ester has been used in the biotinylation of antibodies.
Biochem/physiol Actions:	Biotin is a label widely used in several biochemical applications and has a high affinity for avidin. A spacer chain is required to reduce steric hindrance while coupling biotin (a small molecule) to biopolymers (large molecules). Biotinamidohexanoic acid N-hydroxysuccinimide ester incorporates a 7-atom spacer with the N-succinimide leaving group. It can react with a primary amine in the pH range of 6.5-8.5. This biotinylation reagent incorporates an aminocaproyl spacer and thus can reduce the steric hindrance in binding avidin to some biotinylated compounds.
Disclaimer:	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Packaging:	10, 25, 100, 250 mg in poly bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (TLC)
Storage Temp.	−20°C
UNSPSC	12352203

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