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Boc-Asp(OMe)-fluoromethyl ketone

SIGMA/B2682 - ≥90% (TLC), solid

Synonym: Boc-D-FMK

CAS Number: 187389-53-3
Empirical Formula (Hill Notation): C11H18NO5F
Molecular Weight: 263.26
MDL Number: MFCD03453073
Linear Formula: C11H18NO5F
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-B2682-3MG 3 mg
 $893.00
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assay ≥90% (TLC)
form solid
InChI 1S/C11H18FNO5/c1-11(2,3)18-10(16)13-7(8(14)6-12)5-9(15)17-4/h7H,5-6H2,1-4H3,(H,13,16)/t7-/m0/s1
InChI key MXOOUCRHWJYCAL-ZETCQYMHSA-N
Quality Level 100 
SMILES string COC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)CF
solubility DMF: soluble
storage temp. −20°C
Application: Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) has been used as a caspase inhibitor to study its effects on lactate dehydrogenase (LDH) leakage, apoptosis and virus proliferation in chorion cells , as a component of the transplantation medium for the transplantation of human embryonic stem cells (ESC)-derived medial ganglionic eminence (MGE) cells into hippocampus of mice , as a protease inhibitor to study its effects on cell death in parasites .
Biochem/physiol Actions: Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) permits cell permeability. It is a caspase inhibitor and suppresses apoptosis induced by various kinds of stimuli. Boc-D-fmk poorly inhibits caspases-2, -5, -6 and -10.
Packaging: 3 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥90% (TLC)
Storage Temp. −20°C
UNSPSC 12352209

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