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Bisindolylmaleimide II

SIGMA/B3056 - ≥97% (Mixture of 2 isomers)

CAS Number: 137592-45-1
Empirical Formula (Hill Notation): C27H26N4O2
Molecular Weight: 438.52
MDL Number: MFCD00236430
Linear Formula: C27H26N4O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-B3056-1MG 1 mg
 $144.00
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assay ≥97% (Mixture of 2 isomers)
biological source synthetic (organic)
form powder
InChI 1S/C27H26N4O2/c1-30-13-6-7-17(30)12-14-31-16-21(19-9-3-5-11-23(19)31)25-24(26(32)29-27(25)33)20-15-28-22-10-4-2-8-18(20)22/h2-5,8-11,15-17,28H,6-7,12-14H2,1H3,(H,29,32,33)
InChI key LBFDERUQORUFIN-UHFFFAOYSA-N
Quality Level 200 
shipped in dry ice
SMILES string CN1CCCC1CCn2cc(C3=C(C(=O)NC3=O)c4c[nH]c5ccccc45)c6ccccc26
solubility DMSO: soluble
  ethanol: soluble
storage temp. −20°C
Application: Bisindolylmaleimide II (BIS II) has been used:
• as a protein kinase C (PKC) inhibitor to study its effects on cardiomyocyte phenotypes
• as a PKC inhibitor along with methanandamide (mAEA) to study its effects on murine gastric vagal afferent (GVA) mechanosensitivity
• as a PKC/protein kinase A (PKA) inhibitor to study its effects on bone-marrow cells
Biochem/physiol Actions: Bisindolylmaleimide II (BIS II) acts as a dual protein kinase A/C (PKA/C) inhibitor.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97% (Mixture of 2 isomers)
Storage Temp. −20°C
UNSPSC 12352111

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