BF-170 hydrochloride
SIGMA/B4311 - ≥98% (HPLC), solid
Synonym: 2-
CAS Number: 22191-97-5
Empirical Formula (Hill Notation): C15H12N2 · HCl
Molecular Weight: 256.73
MDL Number: MFCD08705340
Linear Formula: C15H12N2 · HCl
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | orange |
| form | solid |
| InChI | 1S/C15H12N2.ClH/c16-13-8- |
| InChI key | UYYPMQOFLJHJAW-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | Cl[H].Nc1ccc(cc1)-c2ccc3c |
| solubility | H2O: 10 mg/mL |
| storage condition | desiccated |
| protect from light | |
| under inert gas | |
| storage temp. | −20°C |
| Biochem/physiol Actions: | BF-170 is a new probe for neurofibrillary tangles (tau fibrils) with greater binding affinity to tau than to Aβ fibrils. |
| Biochem/physiol Actions: | BF-170 is a new probe for neurofibrillary tangles (tau fibrils). It exhibits greater binding affinity to tau than to Aβ fibrils, EC50 = 221 nM vs. EC50 = 786 nM (Ki for Aβ > 5,000 nM). BF-170 demonstrates fast clearance from the brain; clearly visualizes neurofibrillary tangles, neuropil threads, and paired helical filament-type neuritis. BF-70 may become one of the candidate compounds for in vivo imaging of tau pathology associated with Alzheimer′s disease and is a useful tool in distinguishing among tau and Aβ fibrils specifically in AD. |
| Disclaimer: | Product is air sensitive, store under inert gas. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |   GHS05,GHS07 |
| Signal word | Danger |
| Hazard statements | H302 - H315 - H318 - H335 |
| Precautionary statements | P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 + P310 |
| Hazard Codes | Xn |
| Risk Statements | 22-37/38-41 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |