Advanced Search



(E/Z)-BCI hydrochloride

SIGMA/B4313 - ≥98% (HPLC)

Synonym: (E)-2-benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one; 3-(cyclohexylamino)-2,3-dihydro-2-(phenylmethylene)-1Hinden-1-one; 2-benzylidene-3-(cyclohexylamino)-1-Indanone hydrochloride; NSC 150117 hydrochloride

CAS Number: 95130-23-7
Empirical Formula (Hill Notation): C22H23NO · HCl
Molecular Weight: 353.89
MDL Number: MFCD16875416
Linear Formula: C22H23NO · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-B4313-5MG 5 mg
 $272.00
1/EA		 Add To Favorites
45-B4313-25MG 25 mg
 $1060.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C22H23NO.ClH/c24-22-19-14-8-7-13-18(19)21(23-17-11-5-2-6-12-17)20(22)15-16-9-3-1-4-10-16;/h1,3-4,7-10,13-15,17,21,23H,2,5-6,11-12H2;1H
InChI key JPATUDRDKCLPTI-UHFFFAOYSA-N
Quality Level 100 
SMILES string Cl.O=C1C(=Cc2ccccc2)C(NC3CCCCC3)c4ccccc14
solubility DMSO: 10 mg/mL, clear
storage condition desiccated
storage temp. 2-8°C
Application: (E/Z)-BCI hydrochloride has been used:
• to evaluate the role of the Duox-H2O2-Dusp6 derepression signaling pathway in heart regeneration
• as an MKP-1 inhibitor to investigate the role of MKP-1 on bexarotent-induced effects
• as a dual specificity phosphatase 6 (DUSP6) inhibitor to study its effects on the proliferation of SKOV3 cells
Biochem/physiol Actions: (E/Z)-BCI Hydrochloride is an inhibitor of dual-specificity phosphatase 6 (Dusp6) and Dusp1; hyperactivates FGF signaling.
Biochem/physiol Actions: BCI is an allosteric inhibitor of Dusp6 that acts within the phosphatase domain to prevent the catalytic stimulation of phosphatase activity induced by ERK2 substrate binding. BCI also hyperactivates FGF signaling, since Dusp6 functions as a feedback regulator of FGF signaling.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 51111800

The following items have been added to your cart:

Choose a favorite list for this item:
Catalog Number Description Price
$

Returns/Order support

Please fill out the form below if you want to request order support from Krackeler Scientific.


Quick Order

* Required


New Year Price Updates

We are currently working diligently to update our website pricing information for the New Year. If you place an order, you will be acknowledged with any corrected pricing. If you'd like the most current information sooner, please don't hesitate to drop us an email or give us a call and we'd be happy to assist. Thank you for your patience while we are updating.

800-334-7725
office@krackeler.com


Play Video

To Request a Quote

  1. Search or Browse for items and add to them to your Shopping Cart.
  2. Click the "Request Quote" button at the bottom of the Shopping Cart page.
  3. Fill out required fields.
  4. Optionally you can convert to standard checkout mode by choosing a payment type.
  5. Click "Request Quote" at the bottom of the page.

You will be contacted with a quote.

To Order From a Quote

  1. Register and login to the website.
  2. Receive a quote from your sales representative or customer service.
  3. Have your copy of the quote in hand.
  4. Visit our quote module to search for your quote.
Back to Top