Butenafine hydrochloride

SIGMA/B5188 - ≥98% (HPLC)

Synonym: Butenafine hydrochloride; Mentax; N-(p-tert-butylbenzyl)-N-methyl-1-naphthalenemethylamine hydrochloride; N-[[4-(1,1-Dimethylethyl)phenyl]methyl]-N-methyl-1-naphthalenemethanamine hydrochloride

CAS Number: 101827-46-7
Empirical Formula (Hill Notation): C₂₃H₂₇N · HCl
Molecular Weight: 353.93
MDL Number: MFCD00917064
Linear Formula: C₂₃H₂₇N · HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-B5188-10MG	10 mg	$85.80 1/EA	Add To Favorites
45-B5188-50MG	50 mg	$324.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to off-white
form	powder
InChI	1S/C23H27N.ClH/c1-23(2,3)21-14-12-18(13-15-21)16-24(4)17-20-10-7-9-19-8-5-6-11-22(19)20;/h5-15H,16-17H2,1-4H3;1H
InChI key	LJBSAUIFGPSHCN-UHFFFAOYSA-N
originator	Schering Plough
Quality Level	100
SMILES string	Cl.CN(Cc1ccc(cc1)C(C)(C)C)Cc2cccc3ccccc23
solubility	DMSO: ≥10 mg/mL
storage condition	desiccated
storage temp.	room temp

Application:	Butenafine hydrochloride has been used as a standard in high-performance liquid chromatography (HPLC) method to determine butenafine hydrochloride in butenafine-loaded nanosponges.
Biochem/physiol Actions:	Butenafine exhibits fungicidal and antimycotic activity. This fungal squalene epoxidase inhibitor serves as an effective fungicide against T. rubrum, T. mentagrophytes, Microsporum canis, Aspergillus fumigatus, Sporothrix schenckii, Candida parapsilosis, and C. albicans. It is considered more effective and rapid than other antifungal drugs at curing dermatophytosis and preventing recurrences. In humans, it is used topically to treat tinea conditions and superficial candidiasis. Butenafine is considered a promising antimycotic compound to treat tinea pedis due to its efficiency, safety profile, relapse rates, and cost-effectiveness.
Biochem/physiol Actions:	Butenafine is an antifungal; squalene epoxidase inhibitor. It inhibits the synthesis of ergosterol needed in fungal cell membranes.
Biochem/physiol Actions:	Butenafine possesses antifungal property. It is a squalene epoxidase inhibitor. Butenafine can inhibit the synthesis of ergosterol needed in fungal cell membranes.
Features and Benefits:	This compound was developed by Schering Plough . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
General description:	Butenafine hydrochloride is chemically known as N-4-tertbutylbenzyl-N-methyl-1-naphthalenemethylamine hydrochloride. Butenafine, a benzylamine derivative, is a new generation antimycotic compound. It is easily soluble in methanol, ethanol, dichloromethane, and chloroform, but not in water. The allyl radical in butenafine hydrochloride is substituted by a butylbenzyl group.
Packaging:	10, 50 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H312
Precautionary statements	P280
Hazard Codes	Xn
Risk Statements	21
RIDADR	NONH for all modes of transport
WGK Germany	nwg
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	room temp
UNSPSC	51111800

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