Bendamustine hydrochloride hydrate
SIGMA/B5437 - ≥98% (HPLC)
Synonym: 1H-
CAS Number: 1374784-02-7
Empirical Formula (Hill Notation): C16H21Cl2N3O2·HCl · xH2O
Molecular Weight: 394.72 (anhydrous basis)
MDL Number: MFCD16879055
Linear Formula: C16H21Cl2N3O2·HCl · xH2O
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | off-white |
| form | powder |
| InChI | 1S/C16H21Cl2N3O2.ClH.H2O/ |
| InChI key | TWBJYCLUHINEDN-UHFFFAOYSA |
| originator | Teva |
| Quality Level | 100  |
| SMILES string | O.Cl.Cn1c(CCCC(O)=O)nc2cc |
| solubility | H2O: >30 mg/mL |
| storage condition | desiccated |
| storage temp. | room temp |
| Application: | Bendamustine hydrochloride hydrate has been used as: • a chemotherapy agent for chronic lymphocytic leukemia (CLL) samples to monitor spliced and unspliced gene expression • an inhibitor to E3 ubiquitin-protein ligase RNF3 (HOIP) in matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF) assay • a cytotoxic chemotherapeutic drug in high-throughput screening to test interaction with BAY87-2243 |
| Biochem/physiol Actions: | Bendamustine hydrochloride is a DNA-alkylator with a distinct pattern of activity. Bendamustine activates DNA-damage stress response and apoptosis; inhibits mitotic checkpoints; and induces mitotic catastrophe. |
| Biochem/physiol Actions: | Bendamustine is a therapeutic agent employed in treating lymphomas and chronic lymphocytic leukemia. It may be useful in central nervous system (CNS) malignancies treatment regimen due to its penetration capacity into brain tissue. Bendamustine is a promising candidate for non-Hodgkin lymphoma and Hodgkin lymphoma therapies. |
| Features and Benefits: | This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Features and Benefits: | This compound was developed by Teva . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| General description: | Bendamustine comprises 2-chloroethylamine alkylating group, a butyric acid side chain and a benzimidazole ring in its structure and is a nitrogen mustard. It is catabolized in the liver by the enzyme cytochrome P450 1A2 into γ hydroxyl-bendamustine and N-desmethyl-bendamustine. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |   GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H301 - H341 - H351 - H361fd |
| Precautionary statements | P201 - P202 - P264 - P270 - P280 - P301 + P310 |
| Hazard Codes | T,Xn |
| Risk Statements | 60-61-22-40 |
| Safety Statements | 36-37 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |