Bay 11-7082
SIGMA/B5556 - ≥98% (HPLC), powder
Synonym: (E)
CAS Number: 19542-67-7
Empirical Formula (Hill Notation): C10H9NO2S
Molecular Weight: 207.25
MDL Number: MFCD00712162
Linear Formula: C10H9NO2S
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white |
| form | powder |
| InChI | 1S/C10H9NO2S/c1-9-3-5-10( |
| InChI key | DOEWDSDBFRHVAP-KRXBUXKQSA |
| Quality Level | 100  |
| SMILES string | Cc1ccc(cc1)S(=O)(=O)C=C |
| solubility | DMSO: >20 mg/mL |
| H2O: insoluble |
| Application: | Bay 11-7082 has been used as: • a nuclear factor-kappa B (NF-kB) inhibitor to verify the action of the NF-kB signaling pathway in the production of interleukin (IL)-8 • a nuclear factor-kappa B (NF-kB) inhibitor to study the role of NF-kB activation in Mycoplasma hyorhinis -induced epithelial-mesenchymal transition (EMT) and cell migration • a nod-like receptor family pyrin domain containing 3 (NLRP3) selective inhibitor to examine its effects on liver inflammation in mice after hematopoietic stem cell transplantation |
| Biochem/physiol Actions: | Bay 11-7082 acts as a selective inhibitor for nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome pathway. In addition, to the inhibition of nuclear factor-kappa B (NF-kB), Bay 11-7082 also triggers apoptosis in anucleated erythrocytes, human T-cell leukemia virus type I (HTLV-I)-infected T-cell lines and primary adult T-cell leukemia cells. |
| Biochem/physiol Actions: | Bay 11-7082 is an inhibitor of cytokine-induced IκB-α phosphorylation. |
| Features and Benefits: | This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Packaging: | 10 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| UNSPSC | 12352200 |