Bay 11-7085
SIGMA/B5681 - ≥98% (HPLC), solid
Synonym: (E)
CAS Number: 196309-76-9
Empirical Formula (Hill Notation): C13H15NO2S
Molecular Weight: 249.33
MDL Number: MFCD01862602
Linear Formula: C13H15NO2S
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white |
| form | solid |
| InChI | 1S/C13H15NO2S/c1-13(2,3)1 |
| InChI key | VHKZGNPOHPFPER-ONNFQVAWSA |
| Quality Level | 100  |
| SMILES string | CC(C)(C)c1ccc(cc1)S(=O)(= |
| solubility | DMSO: soluble >25 mg/mL |
| H2O: insoluble |
| Application: | Bay 11-7085 has been used as: • nuclear factor-κB inhibitor in Panc-1 cells, macrophages • inhibitory κB kinase IKK inhibitor in human astrocytoma cells U87MGs • phospho-p65 inhibitor human monocyte cell line THP-1 |
| Biochem/physiol Actions: | Bay 11-7085 inactivates peroxisome proliferator-activated receptors γ (PPAR-γ) and increases the microtubule-associated proteins 1A/1B light chain 3B (LC3B), a marker of autophagy resulting in apoptosis in human synovial fibroblasts. It promotes apoptosis in pancreatic carcinoma and may serve as radiotherapy-sensitizing drug. BAY 11-7085 decreases B-cell lymphoma 2 (Bcl-2) by inhibiting pI-κBα (inhibitor of nuclear factor κ B kinase subunit α |
| Biochem/physiol Actions: | Inhibits NF-κB activated expression of ICAM-1, VCAM-1, E-selectin, IL-6 and IL-8. |
| Packaging: | 10 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| UNSPSC | 12352200 |