BVT.948
SIGMA/B6060 - ≥98% (HPLC), solid
Synonym: 4-
CAS Number: 39674-97-0
Empirical Formula (Hill Notation): C14H11NO3
Molecular Weight: 241.24
MDL Number: MFCD00616487
Linear Formula: C14H11NO3
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | red |
| form | solid |
| InChI | 1S/C14H11NO3/c1-14(2)9-10 |
| InChI key | BAQXWJQSUXZVIP-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | CC1(C)C(=O)N=C2c3ccccc3C( |
| solubility | DMSO: 18 mg/mL |
| H2O: insoluble | |
| storage condition | desiccated |
| protect from light | |
| under inert gas | |
| storage temp. | −20°C |
| Biochem/physiol Actions: | BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro. |
| Features and Benefits: | BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro. Works through a different mechanism then the other PTP inhibitors. BVT.948 was able to enhance insulin signaling in cells, although it did not increase tyrosine phosphorylation globally. Furthermore, the compound was active in vivo, enhancing insulin tolerance tests in ob/ob mice, therefore apparently enhancing insulin sensitivity. BVT.948 was able to inhibit several other PTPs tested and also was efficient at inhibiting several cytochrome P450 isoforms in vitro. |
| Packaging: | 1 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H317 |
| Precautionary statements | P280 |
| Hazard Codes | Xi |
| Risk Statements | 43 |
| Safety Statements | 36/37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |