(R)-Butaprost

SIGMA/B6309 - ≥98% (HPLC)

Synonym: (1R,2R,3R)-3-Hydroxy-2-[(1E,4R)-4-hydroxy-4-(1-propylcyclobutyl)-1-butenyl]-5-oxo-cyclopentaneheptanoic acid methyl ester

CAS Number: 69648-38-0
Empirical Formula (Hill Notation): C₂₄H₄₀O₅
Molecular Weight: 408.57
MDL Number: MFCD00867055
Linear Formula: C₂₄H₄₀O₅
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-B6309-1MG	1 mg	$242.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	light yellow
form	oil
InChI	1S/C24H40O5/c1-3-14-24(15-9-16-24)22(27)12-8-11-19-18(20(25)17-21(19)26)10-6-4-5-7-13-23(28)29-2/h8,11,18-19,21-22,26-27H,3-7,9-10,12-17H2,1-2H3/b11-8+/t18-,19-,21-,22-/m1/s1
InChI key	XRISENIKJUKIHD-LHQZMKCDSA-N
originator	Bayer
Quality Level	100
SMILES string	CCCC1(CCC1)[C@H](O)CC=C[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC
solubility	DMSO: freely soluble
	ethanol: freely soluble
storage temp.	−20°C

Application:	(R)-Butaprost has been used as a prostanoid receptor (EP)-specific agonist to study its effects on protein kinase A (PKA) regulatory subunits in MCF7 cells. It may be used as EP2 agonist in Madin-Darby canine kidney and mouse cortical collecting duct (mpkCCD14) cells. It may also be used as EP2 agonist in human fetal lung fibroblasts (HFL-1) cells to test its effect on vascular endothelial growth factor (VEGF) production.
Biochem/physiol Actions:	(R)-Butaprost is a selective EP₂ prostanoid receptor agonist.
Biochem/physiol Actions:	Butaprost comprises hydroxy-cyclopentanone ring and ω-chain. It aids protection in events of glutamate based N-methyl-D-aspartate receptor toxicity. Butaprost inhibits conjunctival fibrosis and lowers the intraocular pressure in post glaucoma filtration surgery. It also promotes wound healing by reducing the subconjunctival scarring Tenon′s fibroblasts. Butaprost plays a protective role in pulmonary fibrosis and aids protection against the aggregated amyloid β (Aβ) peptides in Alzheimer′s disease.
Features and Benefits:	This compound was developed by Bayer . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging:	1, 5 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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