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Bretazenil

SIGMA/B6434 - ≥96% (HPLC), solid

Synonym: 9H-Imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid; Ro 16-6028

CAS Number: 84379-13-5
Empirical Formula (Hill Notation): C19H20N3O3Br
Molecular Weight: 418.28
MDL Number: MFCD00866987
Linear Formula: C19H20N3O3Br
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-B6434-25MG 25 mg
 $1080.70
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This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: B6434-25MG.

 

assay ≥96% (HPLC)
color white
form solid
InChI 1S/C19H20BrN3O3/c1-19(2,3)26-18(25)15-16-13-8-5-9-22(13)17(24)14-11(20)6-4-7-12(14)23(16)10-21-15/h4,6-7,10,13H,5,8-9H2,1-3H3/t13-/m0/s1
InChI key LWUDDYHYYNNIQI-ZDUSSCGKSA-N
originator Roche
Quality Level 100 
SMILES string [H][C@@]12CCCN1C(=O)c3c(Br)cccc3-n4cnc(C(=O)OC(C)(C)C)c24
solubility DMSO: 24 mg/mL
  H2O: insoluble
storage temp. 2-8°C
Application: Bretazenil has been used to determine non-specific binding due to its affinity to bind to a variety of γ-aminobutyric acid type A (GABAA) receptor subtypes (α1-3;5). It has also been used as a GABAA receptor partial agonist in the subcutaneous Alzet minipumps to treat obese agouti?related protein (AgRP)?ablated and lean naive mice to study its effect on them.
Biochem/physiol Actions: Bretazenil is a benzodiazepine partial agonist.
Biochem/physiol Actions: Bretazenil is capable of binding to γ-aminobutyric acid type A (GABAA) receptors that are sensitive and insensitive to diazepam. This compound possesses negligible sedative or muscle relaxant effects.
Features and Benefits: This compound is a featured product for Neuroscience research. Click here  to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound was developed by Roche . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
General description: Bretazenil, a tetracyclic imidazocarboxylic ester, is an anxi-olytic/anticonvulsant agent. It possesses a half-life of 2.5 hours and is quickly absorbed.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥96% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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