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Bretazenil

SIGMA/B6434 - ≥96% (HPLC), solid

Synonym: 9H-Imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid; Ro 16-6028

CAS Number: 84379-13-5
Empirical Formula (Hill Notation): C19H20N3O3Br
Molecular Weight: 418.28
MDL Number: MFCD00866987
Linear Formula: C19H20N3O3Br
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-B6434-5MG 5 mg
 $206.00
1/EA		 Add To Favorites
45-B6434-25MG 25 mg
 $963.00
1/EA		 Add To Favorites

 

assay ≥96% (HPLC)
color white
form solid
InChI 1S/C19H20BrN3O3/c1-19(2,3)26-18(25)15-16-13-8-5-9-22(13)17(24)14-11(20)6-4-7-12(14)23(16)10-21-15/h4,6-7,10,13H,5,8-9H2,1-3H3/t13-/m0/s1
InChI key LWUDDYHYYNNIQI-ZDUSSCGKSA-N
originator Roche
Quality Level 100 
SMILES string [H][C@@]12CCCN1C(=O)c3c(Br)cccc3-n4cnc(C(=O)OC(C)(C)C)c24
solubility DMSO: 24 mg/mL
  H2O: insoluble
storage temp. 2-8°C
Application: Bretazenil has been used to determine non-specific binding due to its affinity to bind to a variety of γ-aminobutyric acid type A (GABAA) receptor subtypes (α1-3;5). It has also been used as a GABAA receptor partial agonist in the subcutaneous Alzet minipumps to treat obese agouti?related protein (AgRP)?ablated and lean naive mice to study its effect on them.
Biochem/physiol Actions: Bretazenil is a benzodiazepine partial agonist.
Biochem/physiol Actions: Bretazenil is capable of binding to γ-aminobutyric acid type A (GABAA) receptors that are sensitive and insensitive to diazepam. This compound possesses negligible sedative or muscle relaxant effects.
Features and Benefits: This compound is a featured product for Neuroscience research. Click here  to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound was developed by Roche . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
General description: Bretazenil, a tetracyclic imidazocarboxylic ester, is an anxi-olytic/anticonvulsant agent. It possesses a half-life of 2.5 hours and is quickly absorbed.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥96% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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