Synonym: 9H-Imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid; Ro 16-6028
CAS Number: 84379-13-5
Empirical Formula (Hill Notation): C19H20N3O3Br
Molecular Weight: 418.28
MDL Number: MFCD00866987
Linear Formula: C19H20N3O3Br
Product Type: Chemical
| assay |
≥96% (HPLC) |
| color |
white |
| form |
solid |
| InChI |
1S/C19H20BrN3O3/c1-19(2,3)26-18(25)15-16-13-8-5-9-22(13)17(24)14-11(20)6-4-7-12(14)23(16)10-21-15/h4,6-7,10,13H,5,8-9H2,1-3H3/t13-/m0/s1 |
| InChI key |
LWUDDYHYYNNIQI-ZDUSSCGKSA-N |
| originator |
Roche |
| Quality Level |
100  |
| SMILES string |
[H][C@@]12CCCN1C(=O)c3c(Br)cccc3-n4cnc(C(=O)OC(C)(C)C)c24 |
| solubility |
DMSO: 24 mg/mL |
| |
H2O: insoluble |
| storage temp. |
2-8°C |
| Application: |
Bretazenil has been used to determine non-specific binding due to its affinity to bind to a variety of γ-aminobutyric acid type A (GABAA) receptor subtypes (α1-3;5). It has also been used as a GABAA receptor partial agonist in the subcutaneous Alzet minipumps to treat obese agouti?related protein (AgRP)?ablated and lean naive mice to study its effect on them. |
| Biochem/physiol Actions: |
Bretazenil is a benzodiazepine partial agonist. |
| Biochem/physiol Actions: |
Bretazenil is capable of binding to γ-aminobutyric acid type A (GABAA) receptors that are sensitive and insensitive to diazepam. This compound possesses negligible sedative or muscle relaxant effects. |
| Features and Benefits: |
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Features and Benefits: |
This compound was developed by Roche . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| General description: |
Bretazenil, a tetracyclic imidazocarboxylic ester, is an anxi-olytic/anticonvulsant agent. It possesses a half-life of 2.5 hours and is quickly absorbed. |
| Packaging: |
5, 25 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥96% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
