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Rp-8-Bromo-β-phenyl-1,N2-ethenoguanosine 3′,5′-cyclic monophosphorothioate sodium salt

SIGMA/B6684 - ≥98% (HPLC), powder

Synonym: Rp-β-Phenyl-1,N2-etheno-8-bromoguanosine 3′,5′-cyclic monophosphorothioate sodium salt; Rp-8-Br-PET-cGMPS

CAS Number: 185246-32-6
Empirical Formula (Hill Notation): C18H14BrN5NaO6PS
Molecular Weight: 562.27
Linear Formula: C18H14BrN5NaO6PS
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-B6684-1MG 1 mg
 $367.00
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45-B6684-5MG 5 mg
 $1180.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts B6684-1MG

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C18H15BrN5O6PS.Na/c19-17-21-11-14(24(17)16-12(25)13-10(29-16)7-28-31(27,32)30-13)22-18-20-9(6-23(18)15(11)26)8-4-2-1-3-5-8;/h1-6,10,12-13,16,25H,7H2,(H,20,22)(H,27,32);/q;+1/p-1/t10-,12-,13-,16-,31-;/m1./s1
InChI key SVMPQLHYWRTQCX-DBHVCDLJSA-M
mp 240-300 °C (lit.)
potency 30 nM Ki
Quality Level 100 
SMILES string O.[Na+].O[C@@H]1[C@@H]2O[P@]([O-])(=S)OC[C@H]2O[C@H]1n3c(Br)nc4C(=O)n5cc(nc5Nc34)-c6ccccc6
solubility H2O: 15 mg/mL at ≤60 °C
storage temp. −20°C
Biochem/physiol Actions: Rp-8-Br-PET-cGMPS is a metabolically stable, competitive inhibitor of both PKG I (Ki = 30 nM) and PKG II. Blocks cGMP-gated retinal type ion channels (IC50 = 25 micromoles).
Biochem/physiol Actions: Rp-8-Br-PET-cGMPS is metabolically stable, competitive inhibitor of cGMP-dependent protein kinase G. Inhibits both PKG I (Ki = 30 nM) and PKG II and blocks cGMP-gated retinal type ion channels (IC50 = 25 micromoles).
Features and Benefits: This compound is featured on the PKA & PKG  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Legal Information: U.S. Patent 5,625,056, DE Patent 4,217,679.
Packaging: 1, 5 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
mp 240-300 °C (lit.)
Storage Temp. −20°C
UNSPSC 41106305

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