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Bisdemethoxycurcumin

SIGMA/B6938 - ≥98% (HPLC), solid

Synonym: (1E,6E)-1,7-bis(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione

CAS Number: 33171-05-0
Empirical Formula (Hill Notation): C19H16O4
Molecular Weight: 308.33
MDL Number: MFCD03419284
Linear Formula: C19H16O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-B6938-5MG 5 mg
 $121.00
1/EA		 Add To Favorites
45-B6938-25MG 25 mg
 $488.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
form solid
InChI 1S/C19H16O4/c20-16-7-1-14(2-8-16)5-11-18(22)13-19(23)12-6-15-3-9-17(21)10-4-15/h1-12,20-21H,13H2/b11-5+,12-6+
InChI key PREBVFJICNPEKM-YDWXAUTNSA-N
Quality Level 100 
SMILES string Oc1ccc(cc1)C=CC(=O)CC(=O)C=Cc2ccc(O)cc2
solubility DMSO: ≥20 mg/mL
storage temp. 2-8°C
Application: Bisdemethoxycurcumin has been used:
• to test its inhibitory effect on cell cycle and mitochondrial function in gastric adenocarcinoma cells
• to test it neuroprotective role against lead (Pb) induced toxicity in dopaminergic and noradrenergic systems of Meriones shawi
• as a standard for calibration curve generation to quantify plasma curcuminoids using high-performance liquid chromatography-diode array detection (HPLC-DAD) and ultraviolet (UV)

Biochem/physiol Actions: Bisdemethoxycurcumin (BDMC) is a derivative or curcumin, and represents one of the major active components of curcumin products isolated from Curcumae sp. BDMC shares similar anti-inflammatory properties with demethoxycurcumin. It inhibits LPS-induced nitric oxide (NO) production and expression of iNOS and COX2 in RAW264.7 cells by blocking NF-kB activation. BDMC also displays unique properties in that it enhances Abeta clearance by upregulating expression MGAT3 and TLR genes. BDMC potently inhibits AKR1B10.
Biochem/physiol Actions: Bisdemethoxycurcumin (BMDC) is a stable dimethoxy derivative of curcumin and is useful as a supplement in cell culture medium. It also possesses antimicrobial, antioxidative and neuroprotective functionality.
Biochem/physiol Actions: Inhibitor of NF-kB transcriptional activity
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352205

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