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N-tert-Butyl-α-phenylnitrone

SIGMA/B7263 - ≥98% (GC)

Synonym: N-Benzylidene-tert-butylamine N-oxide; PBN; Phenyl N-t-butylnitrone

CAS Number: 3376-24-7
Empirical Formula (Hill Notation): C11H15NO
Molecular Weight: 177.24
EC Number: 222-168-6
MDL Number: MFCD00008799
Linear Formula: C6H5CH=N(O)C(CH3)3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-B7263-1G 1 g
 $159.00
1/EA		 Add To Favorites
45-B7263-5G 5 g
 $543.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: B7263-1G
ATR-IR Spectra for N-Benzylidene-tert-butylamine N-oxide.
FT-IR Spectra for N-Benzylidene-tert-butylamine N-oxide.

 

assay ≥98% (GC)
color white
form powder
InChI 1S/C11H15NO/c1-11(2,3)12(13)9-10-7-5-4-6-8-10/h4-9H,1-3H3/b12-9-
InChI key IYSYLWYGCWTJSG-XFXZXTDPSA-N
mp 73-74 °C (lit.)
Quality Level 100 
SMILES string CC(C)(C)[N+]([O-])=Cc1ccccc1
solubility DMSO: soluble
storage temp. −20°C
Application: N-tert-Butyl-α-phenylnitrone has been used:
• as a component of Dneasy Blood&Tissue buffer to preserve the oxidized state of DNA extracted from human non-tumorigenic epithelial breast (MCF10A) cells
• as a free radical scavenger of reactive oxygen species (ROS) in microglial (MG) cell lines
• to attenuate fibroblast senescence in unstable oral squamous cell carcinomas (GU-OSCC)
Biochem/physiol Actions: N-tert-butyl-α-phenylnitrone (PBN) is a commonly used free-radical spin trap.
Biochem/physiol Actions: N-tert-butyl-α-phenylnitrone (PBN) is a commonly used free-radical spin trap. It has been shown to reduce the number of emboli-induced cerebral microinfarctions in the rabbit cortex and prevent neoplasia by its radical scavenging activity and its ability to inhibit cyclooxygenase-2 activity. Reported to inhibit the induction of nitric oxide synthase (iNOS), thereby preventing the overproduction of nitric oxide (NO). PBN in a dose of 100 mg/kg i.p. reduced necrosis of the substantia nigra, pars reticulate in flurothyl-induced status epilepticus in rats. It protects against some types of post-trauma epileptogenic events in an animal model of epilepsy. The lethal dose of PBN in rats was found to be approximately 100 mg/100 g body weight (0.564 mmol/100Å g).
Packaging: 1, 5 g in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (GC)
mp 73-74 °C (lit.)
Storage Temp. −20°C
UNSPSC 12352202

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