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4-Bromo-calcium Ionophore A23187

SIGMA/B7272 - powder

Synonym: 4-Bromo-A23187; 4-Bromo-calcimycin

CAS Number: 76455-48-6
Empirical Formula (Hill Notation): C29H36BrN3O6
Molecular Weight: 602.52
MDL Number: MFCD00077667
Linear Formula: C29H36BrN3O6
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-B7272-1MG 1 mg
 $308.00
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color yellow
form powder
InChI 1S/C29H36BrN3O6/c1-14-8-9-29(16(3)11-15(2)27(39-29)17(4)26(34)19-7-6-10-32-19)38-20(14)13-22-33-25-21(37-22)12-18(30)24(31-5)23(25)28(35)36/h6-7,10,12,14-17,20,27,31-32H,8-9,11,13H2,1-5H3,(H,35,36)/t14-,15-,16-,17-,20-,27+,29+/m1/s1
InChI key LDXQFZZGVTWFCF-FHYGWRBKSA-N
Quality Level 200 
SMILES string CNc1c(Br)cc2oc(C[C@H]3O[C@@]4(CC[C@H]3C)O[C@@H]([C@H](C)C[C@H]4C)[C@H](C)C(=O)c5ccc[nH]5)nc2c1C(O)=O
solubility DMSO: soluble
  ethanol: 20 mg/mL
storage temp. 2-8°C
Application: 4-Bromo-calcium Ionophore A23187 has been used for the activation of Ca2+/calmodulin kinase II (CaMKII) in HeLa cell line. It has also been used as a calcium mobilizer to investigate its effect on superoxide dismutase 1 (SOD1) aggregates in VSC 4.1 cells.
Application: Nonfluorescent Ca2+ ionophore that can be used to calibrate the quantitation of cytoplasmic free Ca2+ with fluorescent probes.
Biochem/physiol Actions: 4-Bromo-calcium Ionophore A23187 is a modulator of apoptosis. It inhibits apoptosis in a concentration dependent manner in neutrophils which are aging in vitro and increases the intracellular Ca2+ levels.
Other Notes: Analog of calcium ionophore A23187
Packaging: 1 mg in glass bottle
Storage Temp. 2-8°C
UNSPSC 12352202

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