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BSc3094 monohydrobromide

SIGMA/B7937 - ≥98% (HPLC)

Synonym: 2-[4-(4-Nitrophenyl)-2-thiazolyl]hydrazide-1H-benzimidazole-6-carboxylic acid monohydrobromide

CAS Number: 1173021-98-1
Empirical Formula (Hill Notation): C17H12N6O3S·HBr
Molecular Weight: 461.29
MDL Number: MFCD12912398
Linear Formula: C17H12N6O3S·HBr
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-B7937-5MG 5 mg
 $214.00
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assay ≥98% (HPLC)
form solid
InChI 1S/C17H12N6O3S.BrH/c24-16(11-3-6-13-14(7-11)19-9-18-13)21-22-17-20-15(8-27-17)10-1-4-12(5-2-10)23(25)26;/h1-9H,(H,18,19)(H,20,22)(H,21,24);1H
InChI key HVNYYJJWBWMGCO-UHFFFAOYSA-N
Quality Level 100 
SMILES string Br.[O-][N+](=O)c1ccc(cc1)-c2csc(NNC(=O)c3ccc4[nH]cnc4c3)n2
solubility DMSO: 22 mg/mL
storage condition protect from light
storage temp. 2-8°C
Application: BSc3094 is used in tau protein amyloidogenicity/tauopathy research to study the processes of tau aggregation and cross-linking in neurodegenerative disease development.
Biochem/physiol Actions: BSc3094 is a potent inhibitor of tau aggregation and dissolves preformed tau paired helical filaments. BSc3094 interacts closely with the tau protein at the edge involving protons I-IV, while the second attachment site seems to be at the nitro group. In N2A cells (model system for tau aggregation), BSc3094 exhibited low toxicity.
Biochem/physiol Actions: BSc3094 is a potent inhibitor of tau aggregation.
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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