BML-210

SIGMA/B8063 - ≥98% (HPLC), powder

Synonym: N1-(2-aminophenyl)-N8-phenyl-octanediamide

CAS Number: 537034-17-6
Empirical Formula (Hill Notation): C₂₀H₂₅N₃O₂
Molecular Weight: 339.43
MDL Number: MFCD08062139
Linear Formula: C₂₀H₂₅N₃O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-B8063-5MG	5 mg	$138.00 1/EA		Add To Favorites
45-B8063-25MG	25 mg	$415.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to very faintly yellow
form	powder
InChI	1S/C20H25N3O2/c21-17-12-8-9-13-18(17)23-20(25)15-7-2-1-6-14-19(24)22-16-10-4-3-5-11-16/h3-5,8-13H,1-2,6-7,14-15,21H2,(H,22,24)(H,23,25)
InChI key	RFLHBLWLFUFFDZ-UHFFFAOYSA-N
Quality Level	100
SMILES string	Nc1ccccc1NC(=O)CCCCCCC(=O)Nc2ccccc2
solubility	DMSO: >20 mg/mL
storage temp.	2-8°C

Biochem/physiol Actions:	BML-210 is a histone deacetylase inhibitor. Treatment of A549 cells with BML-210 results in a dose-dependent increase in acetylated histone levels (EC50 = 36 μM). In HeLa extracts, the IC50 for inhibition of HDAC activity is 80 μM.
Biochem/physiol Actions:	BML-210 is a synthetic benzamide and is a potential tumor inhibitor. It is used as a therapeutic agent to treat promyelocytic leukemia. In human leukemia cell lines (NB4, HL-60, THP-1, and K562), BML-210 modulates histone deacetylase and promotes apoptosis. BML-210 favors frataxin expression in neurodegenerative disease Friedreich′s ataxia (FRDA). It interacts with myocyte enhancer factor-2 (MEF2) via hydrogen-bonding and prevents histone deacetylase 4 (HDAC4) binding.
Biochem/physiol Actions:	BML-210 is an HDAC inhibitor.
Features and Benefits:	This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging:	5, 25 mg in glass bottle

Hazard statements	H413
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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