BNTX maleate salt hydrate

SIGMA/B8312 - ≥98% (HPLC)

Synonym: 7(E)-Benzylidenenaltrexone maleate salt hydrate; BNTX-7 maleate salt hydrate; Morphinan-6-one,17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-7-(phenylmethylene)-,(5a,7E)- maleate salt hydrate

Empirical Formula (Hill Notation): C₃₁H₃₁NO₈ · xH₂O
Molecular Weight: 545.58 (anhydrous basis)
MDL Number: MFCD12912399
Linear Formula: C₃₁H₃₁NO₈ · xH₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-B8312-5MG	5 mg	$151.00 1/EA	Add To Favorites

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This image depicts B8312-5MG.

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	yellow
form	powder
InChI	1S/C27H27NO4.C4H4O4.H2O/c29-20-9-8-18-13-21-27(31)14-19(12-16-4-2-1-3-5-16)23(30)25-26(27,22(18)24(20)32-25)10-11-28(21)15-17-6-7-17;5-3(6)1-2-4(7)8;/h1-5,8-9,12,17,21,25,29,31H,6-7,10-11,13-15H2;1-2H,(H,5,6)(H,7,8);1H2/b19-12+;2-1-;/t21-,25+,26+,27-;;/m1../s1
InChI key	AGUNLJBLOJAUKM-ZKJXOIBSSA-N
Quality Level	100
SMILES string	O.OC(=O)C=C/C(O)=O.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)C(C[C@@]35O)=Cc6ccccc6)CC7CC7
solubility	DMSO: >20 mg/mL
storage condition	desiccated
storage temp.	−20°C

Application:	BNTX, a selective nonpeptide σ1 opioid receptor (DOR1) antagonist, is used in σ opioid receptor research to help differentiate and characterized the function and role of the σ1 opioid receptor versus other σ opioid receptor subtypes. BNTX was used to help define the role of σ1 opioid receptors in neurological processes such as anxiety. It was used to help define the role of σ opioid receptors in myocardial infarct development and size.
Biochem/physiol Actions:	BNTX is a selective d1 non peptide opioid receptor antagonist.
Biochem/physiol Actions:	BNTX is a selective nonpeptide δ₁ opioid receptor antagonist. It antagonizes the effect of D-Pen^2,5-enkephalin (a δ₁ agonist 4-6 fold, but did not affect the activity of δ₂ or μ agonists.<<<107>>> BNTX is used to discriminate among opioid receptor subtypes in effects such as alcohol and drug dependence. It binds 100× more tightly to δ₁ than to δ₂ receptors. In the tail-flick assay, antinocieceptive ED50 = 646.4 pmol/mouse.
Features and Benefits:	This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07,GHS09
Signal word	Warning
Hazard statements	H319 - H400
Precautionary statements	P273 - P305 + P351 + P338
Hazard Codes	Xi
Risk Statements	36-50/53
Safety Statements	26-60-61
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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