BD 1047 dihydrobromide

SIGMA/B8562 - ≥95% (HPLC)

Synonym: BD 1047 dihydrobromide

CAS Number: 138356-21-5
Empirical Formula (Hill Notation): C₁₃H₂₀Cl₂N₂· 2 HBr
Molecular Weight: 437.04
MDL Number: MFCD00792739
Linear Formula: C₁₃H₂₀Cl₂N₂· 2 HBr
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-B8562-5MG	5 mg	$125.00 1/EA		Add To Favorites
45-B8562-25MG	25 mg	$495.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥95% (HPLC)
color	white
form	powder
InChI	1S/C13H20Cl2N2.2BrH/c1-16(2)8-9-17(3)7-6-11-4-5-12(14)13(15)10-11;;/h4-5,10H,6-9H2,1-3H3;2*1H
InChI key	WOALTFHGLDVJHK-UHFFFAOYSA-N
Quality Level	100
SMILES string	Br.Br.CN(C)CCN(C)CCc1ccc(Cl)c(Cl)c1
solubility	H₂O: >5 mg/mL
storage condition	desiccated
storage temp.	2-8°C

Application:	BD 1047 dihydrobromide has been used as an antagonist of sigma-1 receptor in hepatocellular carcinoma cells.
Application:	BD 1047, a selective, putative σ1 receptor antagonist, is used in sigma receptor research to help differentiate and characterized the function and role of the sigma1 receptor versus other sigma receptor subtypes. BD 1047 is used to help define the role of σ1 receptors in neurological processes.
Biochem/physiol Actions:	BD-1047 is a selective, putative σ receptor antagonist with antidystonic activity.
Biochem/physiol Actions:	BD-1047 is a selective, putative σ receptor antagonist with antidystonic activity. BD-1047 has >50-fold selectivity at σ1 over σ2 and also >100-fold selectivity over opiate, phencyclidine, muscarinic, dopamine, α1- & α2-adrenoceptor, 5-HT1, and 5-HT2. Though s receptor antagonism is consistent with antipsychotic, especially anti-schizophrenic, activity, BD-1047 shows only modest activity in animal screens for antipsychotics.
Biochem/physiol Actions:	In human immunodeficiency (HIV)-1 seropositive patients, BD 1047 along with other antioxidants may aid in reduction of cathepsin B- based neuropathology.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS05,GHS07
Signal word	Danger
Hazard statements	H315 - H318 - H335
Precautionary statements	P280 - P302 + P352 - P305 + P351 + P338 + P310
Hazard Codes	Xi
Risk Statements	37/38-41
Safety Statements	26-36/37
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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