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BAY 41-2272

SIGMA/B8810 - ≥97% (HPLC)

Synonym: 3-(4-Amino-5-cyclopropylpyrimidin-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine

CAS Number: 256376-24-6
Empirical Formula (Hill Notation): C20H17FN6
Molecular Weight: 360.39
MDL Number: MFCD06411391
Linear Formula: C20H17FN6
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-B8810-5MG 5 mg
 $259.00
1/EA		 Add To Favorites
45-B8810-25MG 25 mg
 $776.00
1/EA		 Add To Favorites

 

assay ≥97% (HPLC)
color white to light brown
form powder
InChI 1S/C20H17FN6/c21-16-6-2-1-4-13(16)11-27-20-14(5-3-9-23-20)17(26-27)19-24-10-15(12-7-8-12)18(22)25-19/h1-6,9-10,12H,7-8,11H2,(H2,22,24,25)
InChI key ATOAHNRJAXSBOR-UHFFFAOYSA-N
mp 210.5-211.4 °C
originator Bayer
Quality Level 100 
SMILES string Nc1nc(ncc1C2CC2)-c3nn(Cc4ccccc4F)c5ncccc35
solubility DMSO: 5 mg/mL, clear (warmed)
storage temp. 2-8°C
Application: BAY 41-2272 has been used for the stimulation of guanylate cyclase in heart and neurons.
Biochem/physiol Actions: BAY 41-2272 is an activator of soluble guanylate cyclase at a novel, NO-independent regulatory site. BAY 41-2272 is the first product that stimulates sGC through a non-NO mechanism. BAY 41-2272 inhibits platelet aggregation and induces vasorelaxation without nitrate tolerance.
Biochem/physiol Actions: BAY 41-2272 is an activator of soluble guanylate cyclase; stimulates sGC through a non-NO mechanism; inhibits platelet aggregation, and induces vasorelaxation without nitrate tolerance.
Features and Benefits: This compound was developed by Bayer . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 5, 25 mg in glass bottle
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97% (HPLC)
mp 210.5-211.4 °C
Storage Temp. 2-8°C
UNSPSC 12352200

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