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Bicalutamide (CDX)

SIGMA/B9061 - ≥98% (HPLC), powder

Synonym: Casodex; Cosudex; N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide

CAS Number: 90357-06-5
Empirical Formula (Hill Notation): C18H14F4N2O4S
Molecular Weight: 430.37
MDL Number: MFCD00869971
Linear Formula: C18H14F4N2O4S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-B9061-10MG 10 mg
 $148.00
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45-B9061-50MG 50 mg
 $582.00
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assay ≥98% (HPLC)
form powder
InChI 1S/C18H14F4N2O4S/c1-17(26,10-29(27,28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25)
InChI key LKJPYSCBVHEWIU-UHFFFAOYSA-N
originator AstraZeneca
Quality Level 100 
SMILES string CC(O)(CS(=O)(=O)c1ccc(F)cc1)C(=O)Nc2ccc(C#N)c(c2)C(F)(F)F
solubility DMSO: >5 mg/mL
  H2O: insoluble
storage condition desiccated
  protect from light
Application: Bicalutamide (CDX) has been used as an androgen receptor (AR) antagonist in prostate, bladder cancer cell lines and human fetal skeletal muscle cells. It has also been used as a supplement in RPMI 1640 for culturing androgen-independent LNCaP (LNCaP-AI) cell line.
Biochem/physiol Actions: Bicalutamide (CDX) is a non-steriodal Androgen Receptor (AR) Antagonist and a pure antiandrogen.
Biochem/physiol Actions: Bicalutamide (CDX) is a non-steriodal Androgen Receptor (AR) antagonist and a pure antiandrogen. It acts via balancing histone acetylation/deacetylation and recruitment of coregulators. Bicalutamide (CDX) abolishes androgen-mediated expression. For example, MMP13 upregulation in prostate cancer, PLZF (promyelocytic leukemia zinc finger protein), and GADD45γ (growth arrest and DNA damage inducible, gamma). Bicalutamide (CDX) is inhibited by non-genomic, transcription-independent stimulation of PI3K/AKT phosphorylation by androgens.
Features and Benefits: This compound is a featured product for Gene Regulation research. Click here  to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the Nuclear Receptors (Steroids)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits: This compound was developed by AstraZeneca . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 10, 50 mg in glass bottle
Purity ≥98% (HPLC)
UNSPSC 12352200

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