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BIX 01294 trihydrochloride hydrate

SIGMA/B9311 - ≥98% (HPLC), powder

Synonym: 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine trihydrochloride hydrate; BIX 01294

CAS Number: 935693-62-2
Empirical Formula (Hill Notation): C28H38N6O2·3HCl · xH2O
Molecular Weight: 600.02 (anhydrous basis)
MDL Number: MFCD14560563
Linear Formula: C28H38N6O2·3HCl · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-B9311-5MG 5 mg
 $227.00
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45-B9311-25MG 25 mg
 $900.00
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assay ≥98% (HPLC)
color white
form powder
InChI 1S/C28H38N6O2/c1-32-12-7-13-34(17-16-32)28-30-24-19-26(36-3)25(35-2)18-23(24)27(31-28)29-22-10-14-33(15-11-22)20-21-8-5-4-6-9-21/h4-6,8-9,18-19,22H,7,10-17,20H2,1-3H3,(H,29,30,31)
InChI key OSXFATOLZGZLSK-UHFFFAOYSA-N
Quality Level 100 
SMILES string N2(CCC(CC2)Nc3nc(nc5c3cc(c(c5)OC)OC)N4CCN(CCC4)C)Cc1ccccc1
solubility H2O: >20 mg/mL
storage condition desiccated
storage temp. 2-8°C
Application: BIX 01294 trihydrochloride hydrate has been used:
• as a histone methylation inhibitor to treat E4 cells for analysing green fluorescent protein (d2EGFP) expression
• to investigate the role of G9a in neuroblastoma tumor growth
• as specific inhibitor of G9a to treat the SK-N-AS, BE(2)-C, SK-N-DZ, SK-N-F1, and SHEP1 neuroblastoma cell lines
Biochem/physiol Actions: BIX 01294 is a selective histone methyl transferase inhibitor.
Biochem/physiol Actions: BIX 01294 is a selective histone methyl transferase inhibitor. In its inhibition of the histone lysine methyltransferases, BIX 01294 does not compete with cofactor S-adenosyl-methionine. The target enzyme is G9a, and it selectively impairs G9a HMTase and the generation of H3K9me2 in vitro.
Features and Benefits: This compound is a featured product for Gene Regulation research. Click here  to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
General description: BIX-01294, a diazepin-quinazolinamine derivative, is a histone-lysine methyltransferase (HMTase) inhibitor that modulates the epigenetic status of chromatin. BIX-01294 inhibits the G9aHMTase dependent levels of histone-3 lysine (9) methylation (H3K9me). Bix-01294 and valproic acid, a histone deacetylase (HDAC) inhibitor, may replace the requirement for ectopic OCT4 (POU5F1) and cMyc respectively in pluripotent stem cell induction (iPS) recipes.
Other Notes: BIX-01294 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the BIX-01294 probe summary  on the Chemical Probes Portal website.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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