Monoclonal Anti-Brain-derived Neurotrophic Factor antibody produced in mouse
SIGMA/B9561 - clone 35909, purified immunoglobulin, lyophilized powder
Synonym: Anti-BDNF
MDL Number: MFCD01633045
Product Type: Chemical
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| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | 35909, monoclonal |
| conjugate | unconjugated |
| form | lyophilized powder |
| isotype | IgG1 |
| Quality Level | 100  |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | flow cytometry: 25 μg/mL |
| UniProt accession no. | P23560  |
| Application: | Monoclonal Anti-Brain-derived Neurotrophic Factor may be used to detect human BDNF by flow cytometry using a working antibody concentration of 25 μg/ml. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Brain derived neurotrophic factor (BDNF) belongs to a family of secreted proteins called neurotrophins that includes, nerve growth factor (NGF), neurotrophin-3 (NT3) and NT4/5. BDNF is expressed in the developing and the mature brain. The influence of BDNF is mediated by its binding to TrkB receptor and sometimes the receptor p75NTR. The downstream pathways promoted by BDNF include PI3K, MAPK and JAK/STAT. The most important role of BDNF is the regulation of synaptic transmission and plasticity, protein synthesis and phosphorylation of local proteins. The secretion of BDNF is highly regulated at both transcriptional and translational levels since it is involved in the proper function of neuronal circuit and development of cognitive functions. The deficits in BDNF functions are implicated in a number of neurodegenerative disorders such as Huntington’s disease, schizophrenia and dementia Monoclonal Anti-Brain-derived Neurotrophic Factor detects human BDNF. |
| Immunogen: | purified, Sf21-derived recombinant human brain-derived neurotrophic factor. |
| Physical form: | Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 51111800 |