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BMS-345541

SIGMA/B9935 - ≥98% (HPLC), powder

Synonym: N-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediamine hydrochloride

CAS Number: 547757-23-3
Empirical Formula (Hill Notation): C14H17N5 · HCl
Molecular Weight: 291.78
MDL Number: MFCD07784499
Linear Formula: C14H17N5 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-B9935-5MG 5 mg
 $233.00
1/EA		 Add To Favorites
45-B9935-25MG 25 mg
 $961.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
form powder
InChI 1S/C14H17N5.ClH/c1-9-3-4-11-12(7-9)19-10(2)8-17-14(19)13(18-11)16-6-5-15;/h3-4,7-8H,5-6,15H2,1-2H3,(H,16,18);1H
InChI key MIDKPVLYXNLFGZ-UHFFFAOYSA-N
originator Bristol-Myers Squibb
Quality Level 100 
SMILES string Cl[H].Cc1ccc2nc(NCCN)c3ncc(C)n3c2c1
solubility DMSO: 18 mg/mL
  H2O: insoluble
storage condition desiccated
storage temp. 2-8°C
Application: BMS-345541 has been used:
• as an IκB kinase (IKK) complex inhibitor to study its effects on the interferon-γ (IFN-γ) production by natural killer (NK) cells
• as an IKK inhibitor to study its effects on the expression of eotaxin and monocyte chemoattractant protein-1 (MCP-1) mRNA in gingival fibroblasts
• as nuclear factor κB (NF-κB) pathway inhibitor to study its effects on tumor necrosis factor α (TNFα) production in human oral squamous carcinoma cells
Biochem/physiol Actions: BMS-345541 is an IKB kinase (IKK) allosteric site inhibitor.
Biochem/physiol Actions: BMS-345541 possesses anti-inflammatory properties. It also blocks the nuclear factor κB (NF-κB)-dependent transcription of pro-inflammatory cytokines. BMS-345541 possesses anti-inflammatory activity and plays a role in arresting bone erosion in certain animal models.
Features and Benefits: This compound is a featured product for Gene Regulation research. Click here  to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound was developed by Bristol-Myers Squibb . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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