Calycosin
SIGMA/B9938 - ≥98% (HPLC)
Synonym: 3′,7-Dihydroxy-4′-methoxy-isoflavone; 3′-Hydroxyformononetin; Cyclosin
CAS Number: 20575-57-9
Empirical Formula (Hill Notation): C16H12O5
Molecular Weight: 284.26
MDL Number: MFCD00210598
Linear Formula: C16H12O5
Product Type: Chemical
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| application(s) | metabolomics vitamins, nutraceuticals, and natural products |
| assay | ≥98% (HPLC) |
| color | white to light yellow |
| form | powder |
| InChI | 1S/C16H12O5/c1-20-14-5-2- |
| InChI key | QAGGICSUEVNSGH-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | O=C1C(C(C=C2)=CC(O)=C2OC) |
| solubility | methanol: 1 mg/mL, clear, colorless |
| storage temp. | 2-8°C |
| Application: | Calycosin has been used: • to study its effect on the repression of glioblastomas by having an inhibitory effect on the expression of tyrosine-protein kinase Met (c-Met) • to analyze its effect on the growth of nasopharyngeal carcinoma cells by modulating the long non-coding RNA, Ewing sarcoma-associated transcript 1(EWSAT1) • to evaluate its effect on the left ventricular ejection fraction in rat model with myocardial ischemia |
| Biochem/physiol Actions: | Calycosin exhibits various therapeutic properties such as anti-inflammatory, antioxidant, antiviral, and neuroprotective effects. It is shown to exercise its anticarcinogenic effects against the cluster of breast cancer, osteosarcoma, hepatocellular carcinoma, and colorectal cancer. It is also being promoted as a probable treatment for myocardial infarction due to its ability to hasten the process of angiogenesis and increase the expression of vascular endothelial growth factor (VEGF). It has been found to show hyperpermeability induced by the conditions of low osmolarity. Finally, calycosin is being suggested to be used as a prodrug for the treatment of hypoxia-related vascular diseases. |
| Biochem/physiol Actions: | Isoflavone and phytoestrogen isolated froma traditional Chinese medicinal herb. Calycosin induces angiogenesis in HUVEC and promotes proliferation of estrogen-receptor positive cells in vivo and in vitro. Also functions as a vasorelaxant on rat thoracic aorta. |
| General description: | Calycosin is a plant estrogen exhibiting both agonistic and antagonistic attitude towards estrogen. It is an isoflavone, occurring as the primary component of the Radix astragali extract. |
| Packaging: | 10 mg in glass bottle |
| Packaging: | 50 mg in poly bottle |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P301 + P310 |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 45 |
| RIDADR | UN 3462 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |