Chlorambucil

SIGMA/C0253

Synonym: 4-(4-[Bis(2-chloroethyl)amino]phenyl)butyric acid; 4-[Bis(2-chloroethyl)amino]benzenebutyric acid

CAS Number: 305-03-3
Empirical Formula (Hill Notation): C₁₄H₁₉Cl₂NO₂
Molecular Weight: 304.21
EC Number: 206-162-0
MDL Number: MFCD00021783
Linear Formula: C₁₄H₁₉Cl₂NO₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-C0253-1G	1 g	$105.00 1/EA	Add To Favorites
45-C0253-10G	10 g	$725.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

form	powder
InChI	1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19)
InChI key	JCKYGMPEJWAADB-UHFFFAOYSA-N
Quality Level	200
SMILES string	OC(=O)CCCc1ccc(cc1)N(CCCl)CCCl
storage temp.	2-8°C

Application:

Chlorambucil has been used:• as an alkylating/chemotherapeutic agent to study its anti-inflammatory effects on amyloidogenesis in mice
• as a positive control to determine the cytotoxicity in murine leukemic monocyte macrophages
• as an adenine-specific DNA-alkylating reagent in the construction of multifunctional conjugate (8950A-Chb(Cl/OH) for mutation-specific DNA alkylation in HeLa S3 cells

Biochem/physiol Actions:

Chlorambucil is a nitrogen mustard alkylating agent that acts as an anti-cancer drug. Chlorambucil binds to membranes, RNA, DNA, and proteins. It exhibits anti-inflammatory and anti-tumor activity by DNA cross-linking. Chlorambucil shows therapeutic effects against chronic lymphocytic leukemia (CLL) via a p53-dependent mechanism.

Symbol	GHS06,GHS08
Signal word	Danger
Hazard statements	H301 - H315 - H319 - H335 - H350
Precautionary statements	P201 - P202 - P261 - P301 + P310 - P302 + P352 - P305 + P351 + P338
Hazard Codes	T
Risk Statements	45-25-36/37/38
Safety Statements	53-26-45
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-8°C
UNSPSC	12352200

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