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Concanavalin A from Canavalia ensiformis (Jack bean)

SIGMA/C0412 - Type IV-S, lyophilized powder, γ-irradiated, BioReagent, suitable for cell culture

Synonym: Con A

CAS Number: 11028-71-0
EC Number: 234-258-2
MDL Number: MFCD00071069
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C0412-5MG 5 mg
 $78.40
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This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

form lyophilized powder
impurities salt, essentially free
product line BioReagent
Quality Level 200 
solubility H2O: soluble, slightly hazy
  PBS: 5 mg/mL, slightly hazy
sterility γ-irradiated
storage temp. −20°C
technique(s) cell culture | mammalian: suitable
type Type IV-S
Analysis Note: Where reported, agglutination activity is expressed in μg/ml and is determined from serial dilutions in phosphate buffered saline, pH 6.8, containing Ca2+ and Mn2+ of a 1 mg per mL solution. This activity is the lowest concentration to agglutinate a 2% suspension of human erythrocytes after 1 hr incubation at 25 °C.
Application: Concanavalin A from Canavalia ensiformis (jack bean) has been used:
• to induce spleen blastogenesis
• to generate ConA blast targets from B6 and lpr spleen cells
• to stimulate splenic lymphocytes from estrogen-and placebo-treated mice
Biochem/physiol Actions: Con A is not blood group specific but has an affinity for terminal α-D-mannosyl and α-D-glucosyl residues. Ca2+ and Mn2+ ions are required for activity. Con A dissociates into dimers at pH 5.6 or below. Between pH 5.8 and pH 7.0, Con A exists as a tetramer; above pH 7.0 higher aggregates are formed. Con A exhibits mitogenic activity which is dependent on its degree of aggregation. Succinylation results in an active dimeric form which remains a dimer above pH 5.6.
Storage Temp. −20°C
UNSPSC 23151817

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