PK 11195
SIGMA/C0424
Synonym: 1-
CAS Number: 85532-75-8
Empirical Formula (Hill Notation): C21H21ClN2O
Molecular Weight: 352.86
MDL Number: MFCD00069334
Linear Formula: C21H21ClN2O
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C0424-50MG
| form | powder |
| InChI | 1S/C21H21ClN2O/c1-4-14(2) |
| InChI key | RAVIZVQZGXBOQO-UHFFFAOYSA |
| Quality Level | 200  |
| SMILES string | CCC(C)N(C)C(=O)c1cc2ccccc |
| Application: | PK 11195 has been used as an inhibitor of peripheral benzodiazepine receptor (PBR) homologs in primitive erythrocytes of embryos and in osteosarcoma cytoplasmic hydrids. It has also been used as an unlabelled competitive binder in in vitro autoradiography experiments in cardiac tissue sections. |
| Biochem/physiol Actions: | PK 11195 is a peripheral benzodiazepine antagonist. It is also an antagonist for human constitutive androstane receptor (hCAR) and human pregnane X receptor (PXR). In human primary hepatocytes, PK 11195 upon demethylation elicits agonist functionality towards the receptor hCAR. PK 11195 also antagonise B-cell lymphoma 2 (Bcl-2) and may serve as a potential compound for mitochondrial targeting therapies and in the treatment of cholangiocarcinoma. |
| Packaging: | 10 mg in poly bottle |
| Packaging: | 50 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| UNSPSC | 12352200 |