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III-31-C

SIGMA/C0619 - ≥98% (HPLC), solid

Synonym: N-[[[(2R,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-4-phenylbutyl](phenylmethyl)amino]carbonyl]-L-leucyl-L-valine methyl ester; WPE-III-31-C

CAS Number: 398515-96-3
Empirical Formula (Hill Notation): C35H52N4O7
Molecular Weight: 640.81
MDL Number: MFCD04974985
Linear Formula: C35H52N4O7
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C0619-5MG 5 mg
 $399.96
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C0619-5MG.

 

assay ≥98% (HPLC)
form solid
InChI 1S/C35H52N4O7/c1-23(2)19-28(31(41)38-30(24(3)4)32(42)45-8)36-33(43)39(21-26-17-13-10-14-18-26)22-29(40)27(20-25-15-11-9-12-16-25)37-34(44)46-35(5,6)7/h9-18,23-24,27-30,40H,19-22H2,1-8H3,(H,36,43)(H,37,44)(H,38,41)/t27-,28-,29+,30?/m0/s1
InChI key DINAVFJXFRFCRE-BLFWRVEASA-N
Quality Level 100 
SMILES string COC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)N(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)Cc2ccccc2)C(C)C
solubility DMSO: ≥9 mg/mL
storage condition desiccated
storage temp. −20°C
Biochem/physiol Actions: III-31-C is a (hydroxyethyl)urea γ-secretase inhibitor that binds to γ-secretase at the substrate docking site. DAPT, also a γ-secretase inhibitor binds to the substrate docking site as well. III-31-C is useful for the affinity isolation and characterization of the protease complex and for testing other ihhibitors that affect the γ-secretase active site. The γ-secretase complex is composed of presenilin as a catalytic component and three integral membrane proteins, nicastrin, Aph-1 and Pen-2.
Biochem/physiol Actions: III-31-C is a (hydroxyethyl)urea γ-secretase inhibitor.
Packaging: 1, 5 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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