Celastrol
SIGMA/C0869 - ≥98% (HPLC), solid
Synonym: 10-
CAS Number: 34157-83-0
Empirical Formula (Hill Notation): C29H38O4
Molecular Weight: 450.61
MDL Number: MFCD03424073
Linear Formula: C29H38O4
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | red |
| form | solid |
| InChI | 1S/C29H38O4/c1-17-18-7-8- |
| InChI key | KQJSQWZMSAGSHN-JJWQIEBTSA |
| Quality Level | 100  |
| SMILES string | CC1=C(O)C(=O)C=C2C1=CC=C3 |
| solubility | DMSO: >10 mg/mL |
| H2O: insoluble | |
| storage temp. | −20°C |
| Application: | Celastrol has been: • used intraperitoneally to inject into experimental mice to study its role in nonalcoholic fatty liver disease (NAFLD) • used in culture medium to study its effect on lipopolysaccharide-induce • used to study its effect in vitro and in vivo in VCaP cells |
| Biochem/physiol Actions: | Celastrol is a potent antioxidant, and anti-inflammatory agent. |
| Biochem/physiol Actions: | Celastrol is a potent antioxidant, and anti-inflammatory agent. It is a novel HSP90 inhibitor (disrupts Hsp90/Cdc37 complex), that exhibits anticancer (anti-angiogenic - suppresses VEGFR expression); antioxidant (inhibits lipid peroxidation) and anti-inflammatory activity (suppresses iNOS and inflammatory cytokine production). |
| Biochem/physiol Actions: | Celastrol is a quinone methide triterpene naturally present in Tripterygium wilfordii. It is useful in treating rheumatoid arthritis. Celastrol prevents the action of proteasome and nuclear factor Κb. |
| Packaging: | 10, 50 mg in glass bottle |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |