Complement C2 deficient serum human
SIGMA/C0913 - for complement assays
CAS Number: 80295-40-5
MDL Number: MFCD00130835
Product Type: Chemical
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| biological source | human |
| form | liquid |
| Quality Level | 200  |
| shipped in | dry ice |
| storage temp. | −70°C |
| technique(s) | activity assay: suitable |
| UniProt accession no. | P06681  |
| Analysis Note: | C2 is depleted by immunoadsorption method as judged by a highly sensitive hemolytic assay and Ouchterlony immunodiffusion method. |
| Application: | C2 is a critical protease for compliment activation, which supports bacterial killing via phagocytes. C2 can be used in research to explore the mechanisms by which bacterial pathogens evade detection by the compliment system. One such mechanism by the bacteria Pseudomonas aeruginosa, uses the alkaline protease (AprA) to degrade and cleave C2 which ultimately interferes with the classical and lectin pathways. Research has shown that C2 deficiency results in an increased risk of infection by Streptococcus pyogenes through impaired phaogocytosis and neutrophil dependent killing. |
| Biochem/physiol Actions: | Heritable complement C2 deficiency can manifest as a number of severe dermatological disorders, including discoid lupus erythematosus, idiopathic atrophoderma, and dermatomyositis. |
| Disclaimer: | RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization. |
| Physical form: | Supplied as a solution in PBS, pH 7.2 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −70°C |
| UNSPSC | 12352202 |