Creatine Kinase MB Fraction from human heart
SIGMA/C0984 - ≥70% (SDS-PAGE), liquid
Synonym: CK MB Fraction
MDL Number: MFCD00151686
Product Type: Chemical
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| application(s) | pharmaceutical |
| assay | ≥70% (SDS-PAGE) |
| biological source | human heart |
| concentration | ≥0.5 mg/mL |
| form | liquid |
| Quality Level | 200  |
| storage temp. | −20°C |
| suitability | suitable for tissue |
| technique(s) | IR spectroscopy: suitable |
| UniProt accession no. | P06732  |
| P12277 |
| Application: | Creatine Kinase MB Fraction from human heart has been used: • as a diagnostic marker for acute myocardial infarction. • to identify overlapping absorbance peaks between blood and the cardiac biomarkers. • to study the phosphorylation pathway of dioxolane guanosine (DXG) in vivo, a potential treatment of HIV-1 infection. |
| Biochem/physiol Actions: | Creatine Kinase (CK) catalyzes the formation of creatinine from creatine phosphate. The enzyme is associated with coronary performance. Elevated serum levels of CK-MB are prime indicators of myocardial cellular injury. It is regarded as a “gold standard” for myocardial infarction diagnosis. The levels of cardiac troponin I (cTnI) or cardiac troponin T also correlate to higher CK-MB) levels. CK-MB levels may also be elevated in chronic renal failure. |
| General description: | Research area: Cell Signaling Creatine Kinase (CK) comprises M and B subunit and is a dimeric molecule. It is one among the isoenzymes of CK. The enzyme is majorly present in the myocardium. |
| Other Notes: | Solution in 5 mM sodium succinate, 10 mM sodium chloride, 1 mM EDTA, 5 mM β-mercaptoethanol, 50% glycerol, pH 7.0. |
| Hazard statements | H412 |
| Precautionary statements | P273 |
| Risk Statements | 52/53 |
| Safety Statements | 61 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥70% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352204 |