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DMT-dC(bz) Phosphoramidite

SIGMA/C111000

Synonym: Cytidine, N-benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxy-, 3′-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; DMT-dC(bz) amidite; N-benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxycytidine, 3′-[2-cyanoethyl N,N-?bis(1-methylethyl)phosphoramidite]; N4-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxycytidine-3′-O-[O-(2-cyanoethyl)-N,N′-diisopropylphosphoramidite]

CAS Number: 102212-98-6
Empirical Formula (Hill Notation): C46H52N5O8P
Molecular Weight: 833.91
MDL Number: MFCD00036315
Linear Formula: C46H52N5O8P
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C111000-6X10G 10 g
 $1020.00
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45-C111000-6X20G 20 g
 $1980.00
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45-C111000-20X40G 40 g
 $24100.00
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45-C111000-100G 100 g
 $1540.00
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45-C111000-500G 500 g
 $7030.00
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45-C111000-1KG 1 kg
 $14020.00
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λ conforms (UV/VIS Identity)
assay ≥99% (31P-NMR)
  ≥99.0% (reversed phase HPLC)
biological source non-animal source (no BSE/TSE risk)
color white to off-white
form powder or granules
impurities ≤0.3 wt. % water content (Karl Fischer)
InChI 1S/C46H52N5O8P/c1-32(2)51(33(3)4)60(57-29-13-27-47)59-40-30-43(50-28-26-42(49-45(50)53)48-44(52)34-14-9-7-10-15-34)58-41(40)31-56-46(35-16-11-8-12-17-35,36-18-22-38(54-5)23-19-36)37-20-24-39(55-6)25-21-37/h7-12,14-26,28,32-33,40-41,43H,13,29-31H2,1-6H3,(H,48,49,52,53)/t40-,41+,43+,60?/m0/s1
InChI key PGTNFMKLGRFZDX-SALLYJDFSA-N
nucleoside profile base: deoxycytidine
base protecting group: benzoyl
2' protecting group: none
5' protecting group: DMT
deprotection: standard
product line Proligo Reagents
Quality Level 200 
SMILES string COc1ccc(cc1)C(OC[C@H]2O[C@H](C[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)N3C=CC(NC(=O)c4ccccc4)=NC3=O)(c5ccccc5)c6ccc(OC)cc6
storage temp. 2-8°C
technique(s) oligo synthesis: suitable
type for DNA synthesis
General description: DMT-dC(bz) Phosphoramidite belongs to the group of DNA Phosphoramidites.Its key features include:•  Exocyclic amine functions are protected by a benzoyl group (dA(bz) anddC(bz)) or isobutyryl group (dG(ib))
• Recommended cleavage and deprotection conditions are 8 hours at 55 °Cor 24 hours at room temperature using concentrated ammonia solution, for standard base-protected oligonucleotides
• The high coupling efficiency of Proligo′s DNA phosphoramidites leads to high-yield and high-quality oligonucleotides
RIDADR NONH for all modes of transport
WGK Germany 3
Purity ≥99% (31P-NMR); ≥99.0% (reversed phase HPLC)
Storage Temp. 2-8°C
UNSPSC 41116107

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