DMT-dC(bz) Phosphoramidite

SIGMA/C111050 - configured for ABI, configured for (ÄKTA^® and OligoPilot^®)

Synonym: Cytidine, N-benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxy-, 3′-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; DMT-dC(bz) amidite; N-benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxycytidine, 3′-[2-cyanoethyl N,N-?bis(1-methylethyl)phosphoramidite]; N4-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxycytidine-3′-O-[O-(2-cyanoethyl)-N,N′-diisopropylphosphoramidite]

CAS Number: 102212-98-6
Empirical Formula (Hill Notation): C₄₆H₅₂N₅O₈P
Molecular Weight: 833.91
MDL Number: MFCD00036315
Linear Formula: C₄₆H₅₂N₅O₈P
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-C111050-5G	5 g	$135.00 1/EA	Add To Favorites
45-C111050-6X5G	5 g	$766.00 6/EA	Add To Favorites
45-C111050-10G	10 g	$275.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

λ	conforms (UV/VIS Identity)
assay	≥99% (³¹P-NMR)
	≥99.0% (reversed phase HPLC)
biological source	non-animal source (no BSE/TSE risk)
color	white to off-white
compatibility	configured for (ÄKTA^® and OligoPilot^®)
	configured for ABI
form	powder or granules
impurities	≤0.3 wt. % water content (Karl Fischer)
InChI	1S/C46H52N5O8P/c1-32(2)51(33(3)4)60(57-29-13-27-47)59-40-30-43(50-28-26-42(49-45(50)53)48-44(52)34-14-9-7-10-15-34)58-41(40)31-56-46(35-16-11-8-12-17-35,36-18-22-38(54-5)23-19-36)37-20-24-39(55-6)25-21-37/h7-12,14-26,28,32-33,40-41,43H,13,29-31H2,1-6H3,(H,48,49,52,53)/t40-,41+,43+,60?/m0/s1
InChI key	PGTNFMKLGRFZDX-SALLYJDFSA-N
nucleoside profile	base: deoxycytidine base protecting group: benzoyl 2' protecting group: none 5' protecting group: DMT deprotection: standard
product line	Proligo Reagents
Quality Level	200
SMILES string	COc1ccc(cc1)C(OC[C@H]2O[C@H](C[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)N3C=CC(NC(=O)c4ccccc4)=NC3=O)(c5ccccc5)c6ccc(OC)cc6
storage temp.	2-8°C
technique(s)	oligo synthesis: suitable
type	for DNA synthesis

General description:	Proligo′s DNA phosphoramidites lead to high-yield and high-quality oligonucleotides due to their high coupling efficiency. The deprotection step of automated oligonucleotide synthesis is integral to synthesis time and final product quality. Exocyclic amine functions are protected by a benzoyl group (dA(bz) and dC(bz)) or isobutyryl group (dG(ib))Key features of DNA phosphoramidites :• Recommended cleavage and deprotection conditions are 8 hours at 55 °Cor 24 hours at room temperature using concentrated ammonia solution,for standard base-protected oligonucleotides • The high coupling efficiency of Proligo′s DNA phosphoramidites leads tohigh-yield and high-quality oligonucleotides The product belongs to ÄKTA® synthesizers.
Legal Information:	ÄKTA is a registered trademark of Cytiva
Legal Information:	OligoPilot is a registered trademark of Cytiva

RIDADR	NONH for all modes of transport
WGK Germany	WGK 1
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥99% (³¹P-NMR); ≥99.0% (reversed phase HPLC)
Storage Temp.	2-8°C
UNSPSC	41116107

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