Synonym: DMT-dC(ac) Amidite; N-acetyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxycytidine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; N4-Acetyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxycytidine-3′-O-[O-(2-cyanoethyl)-N,N′-diisopropylphosphoramidite]
CAS Number: 154110-40-4
Empirical Formula (Hill Notation): C41H50N5O8P
Molecular Weight: 771.84
MDL Number: MFCD09842112
Linear Formula: C41H50N5O8P
Product Type: Chemical
| λ |
conforms (UV/VIS Identity) |
| assay |
≥98% (31P-NMR) |
| |
≥99.0% (reversed phase HPLC) |
| biological source |
non-animal source (no BSE/TSE risk) |
| color |
white to off-white |
| compatibility |
configured for ABI |
| form |
powder |
| InChI |
1S/C41H50N5O8P/c1-28(2)46(29(3)4)55(52-25-11-23-42)54-36-26-39(45-24-22-38(43-30(5)47)44-40(45)48)53-37(36)27-51-41(31-12-9-8-10-13-31,32-14-18-34(49-6)19-15-32)33-16-20-35(50-7)21-17-33/h8-10,12-22,24,28-29,36-37,39H,11,25-27H2,1-7H3,(H,43,44,47,48)/t36-,37+,39+,55?/m0/s1 |
| InChI key |
MECWEBCHRKVTNV-RLWDVSNXSA-N |
| nucleoside profile |
base: deoxycytidine
base protecting group: acetyl
2' protecting group: none
5' protecting group: DMT
deprotection: fast/standard |
| product line |
Proligo Reagents |
| Quality Level |
200  |
| SMILES string |
COc1ccc(cc1)C(OC[C@H]2O[C@H](C[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)N3C=CC(NC(C)=O)=NC3=O)(c4ccccc4)c5ccc(OC)cc5 |
| storage temp. |
-10 to -25°C |
| technique(s) |
oligo synthesis: suitable |
| type |
for DNA synthesis |
| General description: |
Proligo′s DNA phosphoramidites lead to high-yield and high-quality oligonucleotides due to their high coupling efficiency. The deprotection step of automated oligonucleotide synthesis is integral to synthesis time and final product quality. DMT-dC(ac) Phosphoramidite is an acetyl-protected DNA phosphoramidite used in fast deprotection chemistry for the rapid and high-yield synthesis of high-purity oligonucleotides. Key Features of dC(ac): • Ultrafast deprotection: 10 minutes at 65°C with AMA reagent
• Key component in oligonucleotide synthesis
• Industry-standard for fast deprotection chemistry
• Operating for AMA deprotection methods without changes
• Consistent lot-to-lot high purity and performance
• Manufactured under a certified ISO 9001 quality system
The product belongs to ABI™ Synthesizers. |
| Legal Information: |
ABI is a trademark of Applera Corporation or its subsidiaries in the US and/or certain other countries |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (31P-NMR); ≥99.0% (reversed phase HPLC) |
| Storage Temp. |
-10 to -25°C |
| UNSPSC |
12352200 |
